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Tbio
CDK5RAP1
CDK5 regulatory subunit-associated protein 1

Protein Summary
Description
Specifically inhibits CDK5 activation by CDK5R1. This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339269
  • ENSP00000341840
  • ENSG00000101391
  • ENST00000346416
  • ENSP00000217372
  • ENST00000357886
  • ENSP00000350558
  • ENST00000473997
  • ENSP00000476857

Symbol
  • C20orf34
  • C42
  • CGI-05
  • HSPC167
  • C20orf34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
histone modification site profile
0.86
transcription factor binding site profile
0.84
kinase perturbation
0.71
gene perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.45   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.45   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0