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Tbio
CDK5RAP1
CDK5 regulatory subunit-associated protein 1

Protein Summary
Description
Specifically inhibits CDK5 activation by CDK5R1. This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339269
  • ENSP00000341840
  • ENSG00000101391
  • ENST00000346416
  • ENSP00000217372
  • ENST00000357886
  • ENSP00000350558
  • ENST00000473997
  • ENSP00000476857

Symbol
  • C20orf34
  • C42
  • CGI-05
  • HSPC167
  • C20orf34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
histone modification site profile
0.86
transcription factor binding site profile
0.84
kinase perturbation
0.71
gene perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.13   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.13   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
KIAA0930
Tbio
Novelty:  0.16492958
p_int:  0.999996305
p_ni:  0.000003695
Score:  0.177
Data Source:  BioPlex,STRINGDB
CARNMT1
Tbio
Family:  Enzyme
Novelty:  0.28121779
p_int:  0.996877614
p_ni:  0.003122386
Score:  0.173
Data Source:  BioPlex,STRINGDB
ZMYND19
Tdark
Novelty:  0.3590069
p_int:  0.986749702
p_ni:  0.013250272
p_wrong:  2.6e-8
Data Source:  BioPlex
NDUFAF5
Tbio
Family:  Enzyme
Novelty:  0.13483499
p_int:  0.975831718
p_ni:  0.024165284
p_wrong:  0.000002998
Score:  0.204
Data Source:  BioPlex,STRINGDB
XRCC6
Tbio
Novelty:  0.00127955
p_int:  0.956281355
p_ni:  0.043718645
Score:  0.535
Data Source:  BioPlex,STRINGDB
XRCC5
Tbio
Novelty:  0.00150735
p_int:  0.929693842
p_ni:  0.070306158
Score:  0.826
Data Source:  BioPlex,STRINGDB
GPSM3
Tbio
Novelty:  0.01632501
p_int:  0.92477495
p_ni:  0.07522505
Data Source:  BioPlex
PDZK1P1
Tdark
p_int:  0.917274883
p_ni:  0.082725117
Data Source:  BioPlex
PLA2G10
Tchem
Family:  Enzyme
Novelty:  0.00289317
p_int:  0.883760741
p_ni:  0.116239259
Data Source:  BioPlex
ZZEF1
Tdark
Novelty:  0.33216648
p_int:  0.813991922
p_ni:  0.186008078
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
5
5
93.3
blood protein measurement
1
1
1
48.5
appendicular lean mass
1
1
1
44.2
suntan
1
1
1
42.3
1
1
0
1.3
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
5
93.3
blood protein measurement
1
48.5
appendicular lean mass
1
44.2
suntan
1
42.3
0
1.3
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDK5 regulatory subunit associated protein 1
VGNC:6074
746993
Macaque
CDK5 regulatory subunit associated protein 1
714295
Mouse
MGI:1914221
66971
Rat
RGD:708387
252827
Dog
CDK5 regulatory subunit associated protein 1
VGNC:39057
477195
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDK5 regulatory subunit associated protein 1
Macaque
CDK5 regulatory subunit associated protein 1
Mouse
Rat
Dog
CDK5 regulatory subunit associated protein 1
Publication Statistics
PubMed Score 25.13
PubMed score by year
PubTator Score 128.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title