You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
CDK4
Cyclin-dependent kinase 4

Protein Summary
Description
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic su ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257904
  • ENSP00000257904
  • ENSG00000135446

Symbol
  • CMM3
  • PSK-J3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
kinase perturbation
1
interacting protein
0.99
molecular function
0.99
drug perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2941.76   (req: < 5)
Gene RIFs: 257   (req: <= 3)
Antibodies: 995   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2941.76   (req: >= 5)
Gene RIFs: 257   (req: > 3)
Antibodies: 995   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 526
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4