Tchem CDK3 Cyclin-dependent kinase 3

Protein Summary

Description

Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q00526

Gene Name

• CDK3

Ensembl ID

• ENST00000425876
• ENSP00000410561
• ENSG00000250506
• ENST00000448471
• ENSP00000400088

Symbol

• CDKN3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.97
molecular function	0.93
protein domain	0.73
tissue sample	0.65
small molecule perturbation	0.63

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Tyrosine Protein Kinase / Cyclin-dependent Kinase 3

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Cyclin-dependent Kinase 3

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Cdk Family / Cdk1 Subfamily / Cyclin-dependent Kinase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.93   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 55   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.93   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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ProtVista Viewer

Related Tools (5)

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (6)

Explore Active Ligands

1 – 6 of 6

staurosporine

CDK3Tchem Kinase

pKd : 7.89

RGB-286638

CDK3Tchem Kinase

pKd : 8.52

R547

CDK3Tchem Kinase

pKd : 9.27

TG02

CDK3Tchem Kinase

pKd : 6.61

PHA-793887

CDK3Tchem Kinase

pKd : 8.52

CHEMBL4579344

CDK3Tchem Kinase

pIC50 : 8.3

Protein-Protein Interactions (166)

Explore Interacting Targets

1 – 10 of 166

• See Interactions on String-DB

CCNA2

Tchem

Novelty:  0.00049887

p_int:  0.999999999

p_ni:  1e-9

Score:  0.931

Data Source:  BioPlex,STRINGDB

CDK2

Tchem

Family:  Kinase

Novelty:  0.00032118

p_int:  0.999999995

p_ni:  5e-9

Score:  0.704

Data Source:  BioPlex,STRINGDB

CKS1B

Tbio

Family:  Enzyme

Novelty:  0.00766779

p_int:  0.999999976

p_ni:  2.4e-8

Score:  0.937

Data Source:  BioPlex,STRINGDB

HSP90AB4P

Tdark

p_int:  0.999999075

p_ni:  9.22e-7

p_wrong:  2e-9

Data Source:  BioPlex

CDT1

Tbio

Novelty:  0.00398013

p_int:  0.999995338

p_ni:  0.000004662

Score:  0.749

Data Source:  BioPlex,STRINGDB

CCNE1

Tchem

Novelty:  0.00237201

p_int:  0.999993492

p_ni:  0.000006508

Score:  0.962

Data Source:  BioPlex,STRINGDB

CCNE2

Tbio

Novelty:  0.00795182

p_int:  0.999961341

p_ni:  0.000038652

p_wrong:  7e-9

Score:  0.945

Data Source:  BioPlex,STRINGDB

CDKN1B

Tbio

Family:  Enzyme

Novelty:  0.00069449

p_int:  0.999900196

p_ni:  0.000099804

Score:  0.846

Data Source:  BioPlex,STRINGDB

B3GNT2

Tbio

Family:  Enzyme

Novelty:  0.02724566

p_int:  0.999852773

p_ni:  0.000147227

Data Source:  BioPlex

CDKN1C

Tbio

Family:  Enzyme

Novelty:  0.00220485

p_int:  0.999846029

p_ni:  0.000153691

p_wrong:  2.8e-7

Score:  0.753

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

PathwayCommons (5)

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Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: inoh	Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )	178 targets	PathwayCommons: inoh
PathwayCommons: inoh	VEGF signaling pathway ( VEGF signaling pathway )	183 targets	PathwayCommons: inoh
PathwayCommons: inoh	AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )	173 targets	PathwayCommons: inoh
PathwayCommons: inoh	AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) )	173 targets	PathwayCommons: inoh
PathwayCommons: inoh	Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )	236 targets	PathwayCommons: inoh

Name	Explore in Pharos	Explore in Source
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )	178 targets	PathwayCommons: inoh
VEGF signaling pathway ( VEGF signaling pathway )	183 targets	PathwayCommons: inoh
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )	173 targets	PathwayCommons: inoh
AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) )	173 targets	PathwayCommons: inoh
Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )	236 targets	PathwayCommons: inoh

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (9)

Functions (2)

Components (1)

Processes (6)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
cyclin-dependent protein serine/threonine kinase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
white matter hyperintensity measurement	EFO_0005665	2	2	2		73.4
mean platelet volume	EFO_0004584	1	1	1		60.5
comparative body size at age 10, self-reported	EFO_0009819	1	1	1		42.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
white matter hyperintensity measurement	EFO_0005665	2		73.4
mean platelet volume	EFO_0004584	1		60.5
comparative body size at age 10, self-reported	EFO_0009819	1		42.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
ATP-binding
Cell cycle
Cell division
Complete proteome
Kinase
Mitosis
Nucleotide-binding
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
comparative body size at age 10, self-reported
mean platelet volume
white matter hyperintensity measurement

IDG Resources

No IDG generated resources found

Orthologs (1)

1 – 1 of 1

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	cyclin dependent kinase 3		705330

Species	Name	OMA	EggNOG	Inparanoid
Macaque	cyclin dependent kinase 3

Publication Statistics

PubMed Score 46.93

PubMed score by year

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PubTator Score 26.21

PubTator score by year

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Patents

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Related Publications

Text Mined References (36)

GeneRif Annotations (12)

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PMID	Year	Title