Protein Summary
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]
- ENST00000425876
- ENSP00000410561
- ENSG00000250506
- ENST00000448471
- ENSP00000400088
- CDKN3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 0.97 | ||
molecular function | 0.93 | ||
protein domain | 0.73 | ||
tissue sample | 0.65 | ||
small molecule perturbation | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 46.93 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 55 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 46.93 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 55 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (6)
Protein-Protein Interactions (166)
CCNA2
Novelty: 0.00049887
p_int: 0.999999999
p_ni: 1e-9
Score: 0.931
Data Source: BioPlex,STRINGDB
CDK2
Family: Kinase
Novelty: 0.00032118
p_int: 0.999999995
p_ni: 5e-9
Score: 0.704
Data Source: BioPlex,STRINGDB
CKS1B
Family: Enzyme
Novelty: 0.00766779
p_int: 0.999999976
p_ni: 2.4e-8
Score: 0.937
Data Source: BioPlex,STRINGDB
CDT1
Novelty: 0.00398013
p_int: 0.999995338
p_ni: 0.000004662
Score: 0.749
Data Source: BioPlex,STRINGDB
CCNE1
Novelty: 0.00237201
p_int: 0.999993492
p_ni: 0.000006508
Score: 0.962
Data Source: BioPlex,STRINGDB
CCNE2
Novelty: 0.00795182
p_int: 0.999961341
p_ni: 0.000038652
p_wrong: 7e-9
Score: 0.945
Data Source: BioPlex,STRINGDB
CDKN1B
Family: Enzyme
Novelty: 0.00069449
p_int: 0.999900196
p_ni: 0.000099804
Score: 0.846
Data Source: BioPlex,STRINGDB
B3GNT2
Family: Enzyme
Novelty: 0.02724566
p_int: 0.999852773
p_ni: 0.000147227
Data Source: BioPlex
CDKN1C
Family: Enzyme
Novelty: 0.00220485
p_int: 0.999846029
p_ni: 0.000153691
p_wrong: 2.8e-7
Score: 0.753
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
PathwayCommons (5)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
PathwayCommons: inoh | Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) | ||||
PathwayCommons: inoh | VEGF signaling pathway ( VEGF signaling pathway ) | ||||
PathwayCommons: inoh | AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) | ||||
PathwayCommons: inoh | AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) ) | ||||
PathwayCommons: inoh | Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling ) | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) | ||||
VEGF signaling pathway ( VEGF signaling pathway ) | ||||
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) | ||||
AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) ) | ||||
Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling ) | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (2)
Components (1)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
white matter hyperintensity measurement | 2 | 2 | 2 | 73.4 | |||||
mean platelet volume | 1 | 1 | 1 | 60.5 | |||||
comparative body size at age 10, self-reported | 1 | 1 | 1 | 42.3 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
white matter hyperintensity measurement | 2 | 73.4 | |||||
mean platelet volume | 1 | 60.5 | |||||
comparative body size at age 10, self-reported | 1 | 42.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (1)
1 – 1 of 1
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | cyclin dependent kinase 3 | 705330 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | cyclin dependent kinase 3 | |||||
Publication Statistics
PubMed Score 46.93
PubMed score by year
PubTator Score 26.21
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (36)
GeneRif Annotations (12)
Items per page:
0 of 0
PMID | Year | Title |
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