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Tchem
CDK3
Cyclin-dependent kinase 3

Protein Summary
Description
Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000425876
  • ENSP00000410561
  • ENSG00000250506
  • ENST00000448471
  • ENSP00000400088

Symbol
  • CDKN3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
molecular function
0.93
protein domain
0.73
tissue sample
0.65
small molecule perturbation
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.93   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.93   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (166)
CCNA2
Tchem
Novelty:  0.00049887
p_int:  0.999999999
p_ni:  1e-9
Score:  0.931
Data Source:  BioPlex,STRINGDB
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
p_int:  0.999999995
p_ni:  5e-9
Score:  0.704
Data Source:  BioPlex,STRINGDB
CKS1B
Tbio
Family:  Enzyme
Novelty:  0.00766779
p_int:  0.999999976
p_ni:  2.4e-8
Score:  0.937
Data Source:  BioPlex,STRINGDB
HSP90AB4P
Tdark
p_int:  0.999999075
p_ni:  9.22e-7
p_wrong:  2e-9
Data Source:  BioPlex
CDT1
Tbio
Novelty:  0.00398013
p_int:  0.999995338
p_ni:  0.000004662
Score:  0.749
Data Source:  BioPlex,STRINGDB
CCNE1
Tchem
Novelty:  0.00237201
p_int:  0.999993492
p_ni:  0.000006508
Score:  0.962
Data Source:  BioPlex,STRINGDB
CCNE2
Tbio
Novelty:  0.00795182
p_int:  0.999961341
p_ni:  0.000038652
p_wrong:  7e-9
Score:  0.945
Data Source:  BioPlex,STRINGDB
CDKN1B
Tbio
Family:  Enzyme
Novelty:  0.00069449
p_int:  0.999900196
p_ni:  0.000099804
Score:  0.846
Data Source:  BioPlex,STRINGDB
B3GNT2
Tbio
Family:  Enzyme
Novelty:  0.02724566
p_int:  0.999852773
p_ni:  0.000147227
Data Source:  BioPlex
CDKN1C
Tbio
Family:  Enzyme
Novelty:  0.00220485
p_int:  0.999846029
p_ni:  0.000153691
p_wrong:  2.8e-7
Score:  0.753
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: inoh
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )
PathwayCommons: inoh
VEGF signaling pathway ( VEGF signaling pathway )
PathwayCommons: inoh
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )
PathwayCommons: inoh
AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) )
PathwayCommons: inoh
Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )
Name
Explore in Pharos
Explore in Source
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )
VEGF signaling pathway ( VEGF signaling pathway )
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )
AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) )
Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
2
2
2
73.4
mean platelet volume
1
1
1
60.5
comparative body size at age 10, self-reported
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
2
73.4
mean platelet volume
1
60.5
comparative body size at age 10, self-reported
1
42.3
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cyclin dependent kinase 3
705330
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cyclin dependent kinase 3
Publication Statistics
PubMed Score 46.93
PubMed score by year
PubTator Score 26.21
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title