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Tchem
CDK2
Cyclin-dependent kinase 2

Protein Summary
Description
Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DN ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266970
  • ENSP00000266970
  • ENSG00000123374
  • ENST00000354056
  • ENSP00000243067

Symbol
  • CDKN2
  • CDKN2
  • p33(CDK2)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
drug perturbation
1
hub protein
1
biological process
0.99
biological term
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2901.16   (req: < 5)
Gene RIFs: 301   (req: <= 3)
Antibodies: 1544   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2901.16   (req: >= 5)
Gene RIFs: 301   (req: > 3)
Antibodies: 1544   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 468
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (646)
CCNA2
Tchem
Novelty:  0.00049887
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
CKS1B
Tbio
Family:  Enzyme
Novelty:  0.00766779
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CCNE2
Tbio
Novelty:  0.00795182
p_int:  0.999999999
p_ni:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CDK3
Tchem
Family:  Kinase
Novelty:  0.03380289
p_int:  0.999999995
p_ni:  5e-9
Score:  0.704
Data Source:  BioPlex,STRINGDB
CCNE1
Tchem
Novelty:  0.00237201
p_int:  0.999999979
p_ni:  4e-9
p_wrong:  1.7e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CKS2
Tbio
Family:  Enzyme
Novelty:  0.02482411
p_int:  0.999999865
p_ni:  1.35e-7
Score:  0.973
Data Source:  BioPlex,STRINGDB
RBL2
Tbio
Novelty:  0.00121893
p_int:  0.999999864
p_ni:  1.29e-7
p_wrong:  7e-9
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
RBL1
Tbio
Novelty:  0.00228265
p_int:  0.99999967
p_ni:  1e-9
p_wrong:  3.29e-7
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
CCNB1
Tchem
Novelty:  0.0005503
p_int:  0.999998927
p_ni:  0.000001072
Score:  0.999
Data Source:  BioPlex,STRINGDB
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
p_int:  0.999998736
p_ni:  0.000001264
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 2 of 2
CDK4
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  13
more:  9 more common pathways
CDK6
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  12
more:  8 more common pathways
Pathways (125)
APC/C-mediated degradation of cell cycle proteins (R-HSA-174143)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 61
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
CDK-mediated phosphorylation and removal of Cdc6
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
APC/C-mediated degradation of cell cycle proteins
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
CDK-mediated phosphorylation and removal of Cdc6
Cell Cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (48)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Genetic Interaction (IGI)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
6
4
4
3.4
95.8
7
7
0
1.1
93.3
4
3
0
1.3
93.1
mathematical ability
3
3
3
91.7
3
3
0
1.3
91.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
3.4
95.8
0
1.1
93.3
0
1.3
93.1
mathematical ability
3
91.7
0
1.3
91.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 2
VGNC:8364
467032
Macaque
cyclin dependent kinase 2
711002
Mouse
MGI:104772
12566
Rat
RGD:70486
362817
Dog
cyclin dependent kinase 2
VGNC:39051
100855704
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 2
Macaque
cyclin dependent kinase 2
Mouse
Rat
Dog
cyclin dependent kinase 2
Publication Statistics
PubMed Score 2901.16
PubMed score by year
PubTator Score 2253.65
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title