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Tchem
CDK13
Cyclin-dependent kinase 13

Protein Summary
Description
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000181839
  • ENSP00000181839
  • ENSG00000065883
  • ENST00000340829
  • ENSP00000340557

Symbol
  • CDC2L
  • CDC2L5
  • CHED
  • KIAA1791
  • CHED
  • CDC2L
  • CDC2L5
  • hCDK13
  • CHDFIDD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
molecular function
0.98
transcription factor perturbation
0.97
co-expressed gene
0.87
transcription factor binding site profile
0.85


Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.3   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.3   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
IDG Resources
Chemical Tool
(R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4-(dimethylamino)but-2-enamide
image for (R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4-(dimethylamino)but-2-enamide
Details:
  • ChEBI:  143122
  • Provider:  UNC-CH
  • Activity:  260 nM
  • Selectivity:  0.023
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
3
87.3
platelet crit
1
1
1
40.7
lymphocyte percentage of leukocytes
1
1
1
35
neutrophil percentage of leukocytes
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
87.3
platelet crit
1
40.7
lymphocyte percentage of leukocytes
1
35
neutrophil percentage of leukocytes
1
31.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 13
VGNC:7362
736969
Macaque
cyclin dependent kinase 13
711379
Mouse
MGI:1916812
69562
Rat
RGD:1311226
306998
Dog
cyclin dependent kinase 13
VGNC:39045
475874
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 13
Macaque
cyclin dependent kinase 13
Mouse
Rat
Dog
cyclin dependent kinase 13
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q14004-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (36)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
MGI
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (142)
1 – 10 of 142
CDK12
Tchem
Family:  Kinase
Novelty:  0.0119925
p_int:  0.99999994
p_ni:  5.9e-8
p_wrong:  1e-9
Score:  0.842
Data Source:  BioPlex,STRINGDB
HSP90AA4P
Tdark
p_int:  0.999997737
p_ni:  0.000002232
p_wrong:  3.1e-8
Data Source:  BioPlex
HSP90AB3P
Tdark
p_int:  0.999993957
p_ni:  0.000006042
Data Source:  BioPlex
HSP90AB4P
Tdark
p_int:  0.999989801
p_ni:  0.000010199
Data Source:  BioPlex
NEK3
Tchem
Family:  Kinase
Novelty:  0.09580866
p_int:  0.999965741
p_ni:  0.000034259
Score:  0.266
Data Source:  BioPlex,STRINGDB
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.999877407
p_ni:  0.000122586
p_wrong:  7e-9
Data Source:  BioPlex
SPSB3
Tdark
Novelty:  0.07215887
p_int:  0.999615966
p_ni:  0.000383856
p_wrong:  1.78e-7
Score:  0.163
Data Source:  BioPlex,STRINGDB
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.999100337
p_ni:  0.000899663
Data Source:  BioPlex
JPH4
Tbio
Novelty:  0.07699598
p_int:  0.998269882
p_ni:  0.001730118
Data Source:  BioPlex
HSP90AA5P
Tdark
p_int:  0.998185164
p_ni:  0.001814836
Data Source:  BioPlex
Publication Statistics
PubMed Score  36.30

PubMed score by year
PubTator Score  21.61

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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