CDK12
Cyclin-dependent kinase 12
Protein Summary
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
- ENST00000430627
- ENSP00000407720
- ENSG00000167258
- ENST00000447079
- ENSP00000398880
- CRK7
- CRKRS
- KIAA0904
- CRK7
- CRKR
- CRKRS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 1 | ||
molecular function | 0.96 | ||
virus perturbation | 0.95 | ||
interacting protein | 0.88 | ||
transcription factor binding site profile | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 139.4 (req: < 5)
Gene RIFs: 60 (req: <= 3)
Antibodies: 210 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 139.4 (req: >= 5)
Gene RIFs: 60 (req: > 3)
Antibodies: 210 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 20
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0