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Tchem
CDK12
Cyclin-dependent kinase 12

Protein Summary
Description
Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000430627
  • ENSP00000407720
  • ENSG00000167258
  • ENST00000447079
  • ENSP00000398880

Symbol
  • CRK7
  • CRKRS
  • KIAA0904
  • CRK7
  • CRKR
  • CRKRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
molecular function
0.96
virus perturbation
0.95
interacting protein
0.88
transcription factor binding site profile
0.86


Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.6   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.6   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
IDG Resources
Chemical Tool
(R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4-(dimethylamino)but-2-enamide
image for (R,E)-N-(4-(3-((5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl)amino)piperidine-1-carbonyl)phenyl)-4-(dimethylamino)but-2-enamide
Details:
  • ChEBI:  143122
  • Provider:  UNC-CH
  • Activity:  390 nM
  • Selectivity:  0.023
Active Ligands (1)
1 – 1 of 1
CDK12 inhibitor 2
Rendered image for CDK12 inhibitor 2
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
7
8
9
98.5
high density lipoprotein cholesterol measurement
9
9
17
98.1
creatinine measurement
4
5
6
95.2
2
3
0
1.1
91.6
apolipoprotein A 1 measurement
2
2
2
90.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
98.5
high density lipoprotein cholesterol measurement
17
98.1
creatinine measurement
6
95.2
0
1.1
91.6
apolipoprotein A 1 measurement
2
90.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 12
VGNC:9182
454630
Macaque
cyclin dependent kinase 12
696733
Mouse
MGI:1098802
69131
Rat
RGD:621111
192350
Dog
cyclin dependent kinase 12
VGNC:39044
491027
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 12
Macaque
cyclin dependent kinase 12
Mouse
Rat
Dog
cyclin dependent kinase 12
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NYV4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of DNA Repair Genes
Reactome
Transcriptional Regulation by TP53
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of DNA Repair Genes
Transcriptional Regulation by TP53
Gene Ontology Terms (29)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Physical Interaction (IPI)
MGI
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (161)
1 – 10 of 161
CDK13
Tchem
Family:  Kinase
Novelty:  0.03084808
p_int:  0.99999994
p_ni:  5.9e-8
p_wrong:  1e-9
Score:  0.842
Data Source:  BioPlex,STRINGDB
CDX1
Tbio
Family:  TF
Novelty:  0.00815821
p_int:  0.995676093
p_ni:  0.004323874
p_wrong:  3.3e-8
Data Source:  BioPlex
RPL37A
Tbio
Novelty:  0.03475061
p_int:  0.993485669
p_ni:  0.006514259
p_wrong:  7.2e-8
Data Source:  BioPlex
AHSP
Tbio
Novelty:  0.00996928
p_int:  0.990574453
p_ni:  0.009412216
p_wrong:  0.000013331
Data Source:  BioPlex
H1FNT
Tdark
Novelty:  0.05593238
p_int:  0.987849193
p_ni:  0.012136605
p_wrong:  0.000014201
Data Source:  BioPlex
RRS1
Tbio
Novelty:  0.01643671
p_int:  0.983386099
p_ni:  0.01660031
p_wrong:  0.00001359
Score:  0.292
Data Source:  BioPlex,STRINGDB
RPL7L1
Tdark
Novelty:  0.78428937
p_int:  0.982720309
p_ni:  0.011381534
p_wrong:  0.005898157
Data Source:  BioPlex
ZNF2
Tbio
Family:  TF
Novelty:  0.01062543
p_int:  0.968082994
p_ni:  0.031916921
p_wrong:  8.5e-8
Score:  0.548
Data Source:  BioPlex,STRINGDB
FGF8
Tbio
Novelty:  0.00155113
p_int:  0.952648068
p_ni:  0.044092449
p_wrong:  0.003259484
Data Source:  BioPlex
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
p_int:  0.922852664
p_ni:  0.074718621
p_wrong:  0.002428715
Data Source:  BioPlex
Publication Statistics
PubMed Score  110.60

PubMed score by year
PubTator Score  45.27

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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