Tchem CDK11B Cyclin-dependent kinase 11B

Protein Summary

Description

Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Uniprot Accession IDs

• P21127
• B7ZVY7
• J3KTL7
• J3QR29
• J3QR44
• O95265
• Q12817
• Q12818
• Q12819
• Q12820
• Q12822
• Q8N530
• Q9NZS5
• Q9UBJ0
• Q9UBQ1
• Q9UBR0
• Q9UNY2
• Q9UP57
• Q9UP58
• Q9UP59

Gene Name

• CDK11B

Ensembl ID

• ENST00000340677
• ENSP00000464016
• ENSG00000248333
• ENST00000341832
• ENSP00000463048
• ENST00000407249
• ENSP00000464036

Symbol

• CDC2L1
• CDK11
• PITSLREA
• PK58
• p58
• PK58
• CDK11
• CLK-1
• CDC2L1
• PITSLREA
• p58CLK-1
• CDK11-p46
• CDK11-p58
• p58CDC2L1
• CDK11-p110

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
transcription factor binding site profile	0.88
histone modification site profile	0.84
transcription factor	0.8
hub protein	0.79

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Tyrosine Protein Kinase / Cyclin-dependent Kinase 11b

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Cyclin-dependent Kinase 11b

DTO Classes

Protein / Kinase / Protein Kinase / Cmgc Group / Cdk Family / Pitslre Subfamily / Cyclin-dependent Kinase 11b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.39   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.39   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0