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Tchem
CDK11B
Cyclin-dependent kinase 11B

Protein Summary
Description
Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340677
  • ENSP00000464016
  • ENSG00000248333
  • ENST00000341832
  • ENSP00000463048
  • ENST00000407249
  • ENSP00000464036

Symbol
  • CDC2L1
  • CDK11
  • PITSLREA
  • PK58
  • p58
  • PK58
  • CDK11
  • CLK-1
  • CDC2L1
  • PITSLREA
  • p58CLK-1
  • CDK11-p46
  • CDK11-p58
  • p58CDC2L1
  • CDK11-p110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
transcription factor binding site profile
0.88
histone modification site profile
0.84
transcription factor
0.8
hub protein
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.53   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.53   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (137)
CCNL1
Tbio
Novelty:  0.07551385
p_int:  0.99999997
p_ni:  3e-8
Score:  0.727
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.99998748
p_ni:  0.00001252
Data Source:  BioPlex
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.999924792
p_ni:  0.000075208
Score:  0.31
Data Source:  BioPlex,STRINGDB
LRRTM4
Tbio
Novelty:  0.07741851
p_int:  0.998847791
p_ni:  0.001152209
Data Source:  BioPlex
CRAT
Tbio
Family:  Enzyme
Novelty:  0.01242609
p_int:  0.998216486
p_ni:  0.001783514
Data Source:  BioPlex
ZRSR2
Tbio
Novelty:  0.03449891
p_int:  0.996489956
p_ni:  0.003510042
p_wrong:  2e-9
Score:  0.304
Data Source:  BioPlex,STRINGDB
RSBN1
Tbio
Novelty:  0.1955858
p_int:  0.987640213
p_ni:  0.012359787
Data Source:  BioPlex
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.980604012
p_ni:  0.019395972
p_wrong:  1.6e-8
Score:  0.176
Data Source:  BioPlex,STRINGDB
RPL7L1
Tdark
Novelty:  0.78428937
p_int:  0.966741729
p_ni:  0.033257925
p_wrong:  3.46e-7
Data Source:  BioPlex
ZNF221
Tdark
Family:  TF
Novelty:  10.37639878
p_int:  0.960275944
p_ni:  0.039721573
p_wrong:  0.000002483
Score:  0.306
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Reactome
G2/M Transition
Reactome
Mitotic G2-G2/M phases
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
G2/M Transition
Mitotic G2-G2/M phases
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
3
78.1
body height
2
2
2
73.4
serum albumin measurement
1
1
1
33.1
insomnia measurement
1
1
0
1
26.1
visceral adipose tissue measurement
1
1
1
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
78.1
body height
2
73.4
serum albumin measurement
1
33.1
insomnia measurement
0
1
26.1
visceral adipose tissue measurement
1
11.6
Find similar targets by:
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88353
12537
Dog
cyclin-dependent kinase 11B
489591
Cow
cyclin dependent kinase 11B
493708
Pig
cyclin-dependent kinase 11B
100511569
Opossum
cyclin-dependent kinase 11B
100010569
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
cyclin-dependent kinase 11B
Cow
cyclin dependent kinase 11B
Pig
cyclin-dependent kinase 11B
Opossum
cyclin-dependent kinase 11B
Publication Statistics
PubMed Score 37.53
PubMed score by year
PubTator Score 103.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title