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Tchem
CDK11A
Cyclin-dependent kinase 11A

Protein Summary
Description
Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
molecular function
0.93
ligand (protein) perturbation
0.83
hub protein
0.71
tissue sample
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.5   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.5   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (129)
CCNL1
Tbio
Novelty:  0.07551385
p_int:  1
Score:  0.821
Data Source:  BioPlex,STRINGDB
HSP90AB3P
Tdark
p_int:  0.99999977
p_ni:  2.3e-7
Data Source:  BioPlex
HSP90AA5P
Tdark
p_int:  0.999997381
p_ni:  0.000002619
p_wrong:  1e-9
Data Source:  BioPlex
CCNL2
Tbio
Novelty:  0.03667817
p_int:  0.99999304
p_ni:  0.000006929
p_wrong:  3.1e-8
Score:  0.844
Data Source:  BioPlex,STRINGDB
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.999989387
p_ni:  0.000010613
Score:  0.171
Data Source:  BioPlex,STRINGDB
CDC37
Tbio
Novelty:  0.03730196
p_int:  0.992823392
p_ni:  0.007176608
Score:  0.373
Data Source:  BioPlex,STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
p_int:  0.992074784
p_ni:  0.007925216
Score:  0.952
Data Source:  BioPlex,STRINGDB
HSP90AB1
Tchem
Novelty:  0.00907961
p_int:  0.991395996
p_ni:  0.008604004
Score:  0.185
Data Source:  BioPlex,STRINGDB
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.933982866
p_ni:  0.066017134
Score:  0.177
Data Source:  BioPlex,STRINGDB
CCT6A
Tbio
Novelty:  0.02368046
p_int:  0.899148077
p_ni:  0.100851923
Score:  0.177
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Reactome
G2/M Transition
Reactome
Mitotic G2-G2/M phases
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
G2/M Transition
Mitotic G2-G2/M phases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
3
4
86.8
body height
2
2
2
73.4
reticulocyte count
1
1
1
38.8
reticulocyte measurement
1
1
1
35
electrocardiography
1
1
3
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
86.8
body height
2
73.4
reticulocyte count
1
38.8
reticulocyte measurement
1
35
electrocardiography
3
28.1
Find similar targets by:
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:88353
12537
Rat
RGD:628604
252879
Pig
cyclin-dependent kinase 11B
100511569
Opossum
cyclin-dependent kinase 11B
100010569
Xenopus
cyclin-dependent kinase 11B
XB-GENE-1006892
549737
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Pig
cyclin-dependent kinase 11B
Opossum
cyclin-dependent kinase 11B
Xenopus
cyclin-dependent kinase 11B
Publication Statistics
PubMed Score 50.50
PubMed score by year
PubTator Score 26.01
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title