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Tbio
CDHR5
Cadherin-related family member 5

Protein Summary
Description
Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349570
  • ENSP00000345726
  • ENSG00000099834
  • ENST00000358353
  • ENSP00000351118
  • ENST00000397542
  • ENSP00000380676

Symbol
  • MUCDHL
  • MUPCDH
  • MLPCDH
  • MUCDHL
  • MUPCDH
  • MU-PCDH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.67
cell type or tissue
0.64
protein domain
0.58
tissue sample
0.53
gene perturbation
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.8   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.8   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
JMJD8
Tbio
Novelty:  0.31175159
p_int:  0.999234808
p_ni:  0.000763489
p_wrong:  0.000001703
Score:  0.157
Data Source:  BioPlex,STRINGDB
RETSAT
Tdark
Family:  Enzyme
Novelty:  0.10624626
p_int:  0.996295102
p_ni:  0.003704898
Score:  0.203
Data Source:  BioPlex,STRINGDB
MBLAC2
Tdark
Family:  Enzyme
Novelty:  0.47407992
p_int:  0.988785334
p_ni:  0.011214666
Data Source:  BioPlex
UFSP2
Tbio
Family:  Enzyme
Novelty:  0.12630722
p_int:  0.98062402
p_ni:  0.01937598
Data Source:  BioPlex
LGALS1
Tchem
Novelty:  0.00106509
p_int:  0.976479912
p_ni:  0.023519826
p_wrong:  2.62e-7
Data Source:  BioPlex
FITM2
Tdark
Novelty:  0.01882177
p_int:  0.962181618
p_ni:  0.037802297
p_wrong:  0.000016085
Data Source:  BioPlex
XPO7
Tbio
Novelty:  0.05412704
p_int:  0.956188328
p_ni:  0.043811672
Data Source:  BioPlex
LEMD3
Tbio
Novelty:  0.00579701
p_int:  0.949336431
p_ni:  0.050663569
Data Source:  BioPlex
EFNB1
Tbio
Novelty:  0.00523161
p_int:  0.912123405
p_ni:  0.087876414
p_wrong:  1.81e-7
Score:  0.201
Data Source:  BioPlex,STRINGDB
SORL1
Tbio
Novelty:  0.00380895
p_int:  0.824339297
p_ni:  0.175660703
Score:  0.152
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
7
0
1.2
97.5
2
2
0
1.2
68.8
corneal resistance factor
1
1
1
30.2
primary biliary cirrhosis
1
1
1
21.2
1
1
0
1.1
19.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
97.5
0
1.2
68.8
corneal resistance factor
1
30.2
primary biliary cirrhosis
1
21.2
0
1.1
19.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cadherin related family member 5
699464
Mouse
MGI:1919290
72040
Rat
RGD:620504
171554
Horse
cadherin related family member 5 [Source:HGNC Symbol;Acc:HGNC:7521]
Cow
cadherin related family member 5
VGNC:27112
100125282
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cadherin related family member 5
Mouse
Rat
Horse
cadherin related family member 5 [Source:HGNC Symbol;Acc:HGNC:7521]
Cow
cadherin related family member 5
Publication Statistics
PubMed Score 16.80
PubMed score by year
PubTator Score 8.98
PubTator score by year
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Related Publications
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PMID
Year
Title