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Tbio
CDH8
Cadherin-8

Protein Summary
Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance. [provided ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000577390
  • ENSP00000462701
  • ENSG00000150394

Symbol
  • Nbla04261
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
gene perturbation
0.83
virus perturbation
0.76
protein domain
0.73
co-expressed gene
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.95   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.95   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
PKP4
Tbio
Novelty:  0.03654703
p_int:  0.999999974
p_ni:  2.6e-8
Score:  0.38
Data Source:  BioPlex,STRINGDB
ARVCF
Tbio
Novelty:  0.03248592
p_int:  0.999999953
p_ni:  4.3e-8
p_wrong:  4e-9
Score:  0.313
Data Source:  BioPlex,STRINGDB
NYNRIN
Tdark
Novelty:  0.12231563
p_int:  0.999999862
p_ni:  1.38e-7
Score:  0.235
Data Source:  BioPlex,STRINGDB
CTNNA2
Tbio
Novelty:  0.00783865
p_int:  0.999998846
p_ni:  0.000001154
Score:  0.453
Data Source:  BioPlex,STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
p_int:  0.999989855
p_ni:  0.000010145
Score:  0.972
Data Source:  BioPlex,STRINGDB
CTNNA1
Tbio
Novelty:  0.00925774
p_int:  0.999887294
p_ni:  0.000112706
Score:  0.919
Data Source:  BioPlex,STRINGDB
CTNND1
Tbio
Novelty:  0.00335459
p_int:  0.999371343
p_ni:  0.000628657
Score:  0.943
Data Source:  BioPlex,STRINGDB
TMTC4
Tdark
Novelty:  0.53734704
p_int:  0.992663865
p_ni:  0.007336133
p_wrong:  2e-9
Score:  0.193
Data Source:  BioPlex,STRINGDB
BCAM
Tbio
Novelty:  0.01697541
p_int:  0.988404325
p_ni:  0.011595668
p_wrong:  7e-9
Data Source:  BioPlex
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
p_int:  0.986258001
p_ni:  0.013741999
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
6
7
81
risk-taking behaviour
3
4
4
79
cognitive function measurement
3
3
4
74.3
self reported educational attainment
2
3
3
71.6
smoking status measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
7
81
risk-taking behaviour
4
79
cognitive function measurement
4
74.3
self reported educational attainment
3
71.6
smoking status measurement
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cadherin 8
VGNC:8965
454141
Macaque
cadherin 8
708408
Mouse
MGI:107434
12564
Rat
RGD:69286
84408
Dog
cadherin 8
VGNC:39035
489777
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cadherin 8
Macaque
cadherin 8
Mouse
Rat
Dog
cadherin 8
Publication Statistics
PubMed Score 23.95
PubMed score by year
PubTator Score 14.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title