Tbio CDH4 Cadherin-4

Protein Summary

Description

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• P55283
• B3KWB8
• G3V1P8
• Q2M208
• Q5VZ44
• Q9BZ05

Gene Name

• CDH4

Ensembl ID

• ENST00000543233
• ENSP00000443301
• ENSG00000179242
• ENST00000614565
• ENSP00000484928

Symbol

• CAD4
• RCAD
• R-CAD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.97
protein domain	0.85
PubMedID	0.79
transcription factor perturbation	0.74
co-expressed gene	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1151.64   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 287   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1151.64   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0