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Tbio
CDH4
Cadherin-4

Protein Summary
Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000543233
  • ENSP00000443301
  • ENSG00000179242
  • ENST00000614565
  • ENSP00000484928

Symbol
  • CAD4
  • RCAD
  • R-CAD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
protein domain
0.85
PubMedID
0.79
transcription factor perturbation
0.74
co-expressed gene
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1151.64   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1151.64   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
CTNNA3
Tbio
Novelty:  0.01472452
p_int:  0.999877245
p_wrong:  0.000122755
Score:  0.443
Data Source:  BioPlex,STRINGDB
TAX1BP3
Tbio
Novelty:  0.01605171
p_int:  0.995334479
p_ni:  1.1e-8
p_wrong:  0.00466551
Data Source:  BioPlex
JUP
Tbio
Novelty:  0.0081803
Score:  0.952
Data Source:  STRINGDB
CTNND1
Tbio
Novelty:  0.00335459
Score:  0.947
Data Source:  STRINGDB
CTNNA1
Tbio
Novelty:  0.00925774
Score:  0.941
Data Source:  STRINGDB
CTNNA2
Tbio
Novelty:  0.00783865
Score:  0.939
Data Source:  STRINGDB
CDH2
Tbio
Novelty:  0.00040112
Score:  0.938
Data Source:  STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.938
Data Source:  STRINGDB
CDH17
Tbio
Novelty:  0.00035679
Score:  0.922
Data Source:  STRINGDB
CDON
Tbio
Novelty:  0.00447262
Score:  0.916
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Developmental Biology
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
3
4
92.4
educational attainment
1
4
4
88.1
self reported educational attainment
2
1
2
82.8
household income
1
2
2
59.3
mathematical ability
1
1
1
44
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
4
92.4
educational attainment
4
88.1
self reported educational attainment
2
82.8
household income
2
59.3
mathematical ability
1
44
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:99218
12561
Dog
cadherin 4
VGNC:49712
100685099
Horse
cadherin 4
VGNC:16328
100057648
Cow
cadherin 4
VGNC:27104
525796
Chicken
cadherin 4
CGNC:50945
419222
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
cadherin 4
Horse
cadherin 4
Cow
cadherin 4
Chicken
cadherin 4
Publication Statistics
PubMed Score 1151.64
PubMed score by year
PubTator Score 69.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title