Tbio CDH3 Cadherin-3

Protein Summary

Description

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P22223
• B2R6F4
• Q05DI6

Gene Name

• CDH3

Ensembl ID

• ENST00000264012
• ENSP00000264012
• ENSG00000062038
• ENST00000429102
• ENSP00000398485

Symbol

• CDHP
• CDHP
• HJMD
• PCAD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
gene perturbation	0.89
biological process	0.82
protein domain	0.73
biological term	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 401.79   (req: < 5)

Gene RIFs: 100   (req: <= 3)

Antibodies: 867   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 401.79   (req: >= 5)

Gene RIFs: 100   (req: > 3)

Antibodies: 867   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0