You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CDH19
Cadherin-19

Protein Summary
Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This gene is one of three related type II cadherin genes situated in a cluster on chromosome 18. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein containing five extracellular cadherin repeats. Loss of cadherins may be associated with cancer formation. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262150
  • ENSP00000262150
  • ENSG00000071991
  • ENST00000540086
  • ENSP00000439593

Symbol
  • CDH7L2
  • CDH7
  • CDH7L2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.82
protein domain
0.73
cell line
0.58
virus perturbation
0.55
pathway
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.36   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.36   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
FBXO45
Tbio
Novelty:  0.05784607
p_int:  0.999599644
p_ni:  0.000354474
p_wrong:  0.000045882
Score:  0.171
Data Source:  BioPlex,STRINGDB
KAT14
Tbio
Novelty:  0.17168043
p_int:  0.997865968
p_ni:  0.002134032
Score:  0.309
Data Source:  BioPlex,STRINGDB
MARK1
Tchem
Family:  Kinase
Novelty:  0.02342173
p_int:  0.996925867
p_ni:  0.000040408
p_wrong:  0.003033725
Score:  0.242
Data Source:  BioPlex,STRINGDB
YEATS2
Tbio
Novelty:  0.17584498
p_int:  0.99648042
p_ni:  0.00351958
Score:  0.522
Data Source:  BioPlex,STRINGDB
KLHDC3
Tdark
Novelty:  0.63840156
p_int:  0.996376364
p_ni:  0.003621542
p_wrong:  0.000002094
Data Source:  BioPlex
MYCBP2
Tbio
Family:  Enzyme
Novelty:  0.00413684
p_int:  0.993602894
p_ni:  0.006397103
p_wrong:  3e-9
Data Source:  BioPlex
ZZZ3
Tdark
Family:  TF
Novelty:  0.23862921
p_int:  0.993453869
p_ni:  0.006546131
Score:  0.512
Data Source:  BioPlex,STRINGDB
TADA2A
Tbio
Family:  TF
Novelty:  0.07665459
p_int:  0.993030149
p_ni:  0.006969356
p_wrong:  4.95e-7
Score:  0.555
Data Source:  BioPlex,STRINGDB
MARK3
Tchem
Family:  Kinase
Novelty:  0.01304552
p_int:  0.987938309
p_ni:  0.01206169
p_wrong:  1e-9
Score:  0.161
Data Source:  BioPlex,STRINGDB
DDX11
Tbio
Family:  Enzyme
Novelty:  0.02282234
p_int:  0.963017294
p_ni:  0.0368209
p_wrong:  0.000161806
Score:  0.182
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
0.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cadherin 19
VGNC:7313
468572
Macaque
cadherin 19
702726
Mouse
MGI:3588198
227485
Rat
RGD:1307169
360835
Dog
cadherin 19
VGNC:39027
483948
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cadherin 19
Macaque
cadherin 19
Mouse
Rat
Dog
cadherin 19
Publication Statistics
PubMed Score 13.36
PubMed score by year
PubTator Score 6.74
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title