Tbio CDH19 Cadherin-19

Protein Summary

Description

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This gene is one of three related type II cadherin genes situated in a cluster on chromosome 18. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein containing five extracellular cadherin repeats. Loss of cadherins may be associated with cancer formation. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• Q9H159
• B4E1V5
• F5H1K0

Gene Name

• CDH19

Ensembl ID

• ENST00000262150
• ENSP00000262150
• ENSG00000071991
• ENST00000540086
• ENSP00000439593

Symbol

• CDH7L2
• CDH7
• CDH7L2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.82
protein domain	0.73
cell line	0.58
virus perturbation	0.55
pathway	0.47

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.36   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 180   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.36   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (64)

Explore Interacting Targets

1 – 10 of 64

• See Interactions on String-DB

FBXO45

Tbio

Novelty:  0.05784607

p_int:  0.999599644

p_ni:  0.000354474

p_wrong:  0.000045882

Score:  0.171

Data Source:  BioPlex,STRINGDB

KAT14

Tbio

Novelty:  0.17168043

p_int:  0.997865968

p_ni:  0.002134032

Score:  0.309

Data Source:  BioPlex,STRINGDB

MARK1

Tchem

Family:  Kinase

Novelty:  0.02342173

p_int:  0.996925867

p_ni:  0.000040408

p_wrong:  0.003033725

Score:  0.242

Data Source:  BioPlex,STRINGDB

YEATS2

Tbio

Novelty:  0.17584498

p_int:  0.99648042

p_ni:  0.00351958

Score:  0.522

Data Source:  BioPlex,STRINGDB

KLHDC3

Tdark

Novelty:  0.63840156

p_int:  0.996376364

p_ni:  0.003621542

p_wrong:  0.000002094

Data Source:  BioPlex

MYCBP2

Tbio

Family:  Enzyme

Novelty:  0.00413684

p_int:  0.993602894

p_ni:  0.006397103

p_wrong:  3e-9

Data Source:  BioPlex

ZZZ3

Tdark

Family:  TF

Novelty:  0.23862921

p_int:  0.993453869

p_ni:  0.006546131

Score:  0.512

Data Source:  BioPlex,STRINGDB

TADA2A

Tbio

Family:  TF

Novelty:  0.07665459

p_int:  0.993030149

p_ni:  0.006969356

p_wrong:  4.95e-7

Score:  0.555

Data Source:  BioPlex,STRINGDB

MARK3

Tchem

Family:  Kinase

Novelty:  0.01304552

p_int:  0.987938309

p_ni:  0.01206169

p_wrong:  1e-9

Score:  0.161

Data Source:  BioPlex,STRINGDB

DDX11

Tbio

Family:  Enzyme

Novelty:  0.02282234

p_int:  0.963017294

p_ni:  0.0368209

p_wrong:  0.000161806

Score:  0.182

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (11)

PathwayCommons (2)

WikiPathways (9)

Find Similar Targets

Items per page:

5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: panther	Cadherin signaling pathway	150 targets	PathwayCommons: panther
PathwayCommons: panther	Wnt signaling pathway	264 targets	PathwayCommons: panther

Name	Explore in Pharos	Explore in Source
Cadherin signaling pathway	150 targets	PathwayCommons: panther
Wnt signaling pathway	264 targets	PathwayCommons: panther

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (4)

Components (5)

Processes (6)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
cadherin binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
calcium ion binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cytoskeletal protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
protein homodimerization activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	1	1	1		0.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	1		0.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Glycoprotein
Membrane
Metal-binding
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
chronotype measurement

MGI Phenotype Find Similar Targets

No Header	No Header
homeostasis/metabolism phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cadherin 19	VGNC:7313	468572
Macaque	cadherin 19		702726
Mouse	cadherin 19, type 2	MGI:3588198	227485
Rat	cadherin 19	RGD:1307169	360835
Dog	cadherin 19	VGNC:39027	483948

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cadherin 19
Macaque	cadherin 19
Mouse	cadherin 19, type 2
Rat	cadherin 19
Dog	cadherin 19

Publication Statistics

PubMed Score 13.36

PubMed score by year

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PubTator Score 6.74

PubTator score by year

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Related Publications

Text Mined References (12)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title