Protein Summary
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This gene is one of three related type II cadherin genes situated in a cluster on chromosome 18. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein containing five extracellular cadherin repeats. Loss of cadherins may be associated with cancer formation. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Aug 2012]
- ENST00000262150
- ENSP00000262150
- ENSG00000071991
- ENST00000540086
- ENSP00000439593
- CDH7L2
- CDH7
- CDH7L2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.82 | ||
protein domain | 0.73 | ||
cell line | 0.58 | ||
virus perturbation | 0.55 | ||
pathway | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.36 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 180 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.36 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 180 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (64)
FBXO45
Novelty: 0.05784607
p_int: 0.999599644
p_ni: 0.000354474
p_wrong: 0.000045882
Score: 0.171
Data Source: BioPlex,STRINGDB
KAT14
Novelty: 0.17168043
p_int: 0.997865968
p_ni: 0.002134032
Score: 0.309
Data Source: BioPlex,STRINGDB
MARK1
Family: Kinase
Novelty: 0.02342173
p_int: 0.996925867
p_ni: 0.000040408
p_wrong: 0.003033725
Score: 0.242
Data Source: BioPlex,STRINGDB
YEATS2
Novelty: 0.17584498
p_int: 0.99648042
p_ni: 0.00351958
Score: 0.522
Data Source: BioPlex,STRINGDB
KLHDC3
Novelty: 0.63840156
p_int: 0.996376364
p_ni: 0.003621542
p_wrong: 0.000002094
Data Source: BioPlex
MYCBP2
Family: Enzyme
Novelty: 0.00413684
p_int: 0.993602894
p_ni: 0.006397103
p_wrong: 3e-9
Data Source: BioPlex
ZZZ3
Family: TF
Novelty: 0.23862921
p_int: 0.993453869
p_ni: 0.006546131
Score: 0.512
Data Source: BioPlex,STRINGDB
TADA2A
Family: TF
Novelty: 0.07665459
p_int: 0.993030149
p_ni: 0.006969356
p_wrong: 4.95e-7
Score: 0.555
Data Source: BioPlex,STRINGDB
MARK3
Family: Kinase
Novelty: 0.01304552
p_int: 0.987938309
p_ni: 0.01206169
p_wrong: 1e-9
Score: 0.161
Data Source: BioPlex,STRINGDB
DDX11
Family: Enzyme
Novelty: 0.02282234
p_int: 0.963017294
p_ni: 0.0368209
p_wrong: 0.000161806
Score: 0.182
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (11)
PathwayCommons (2)
WikiPathways (9)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
PathwayCommons: panther | Cadherin signaling pathway | ||||
PathwayCommons: panther | Wnt signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cadherin signaling pathway | ||||
Wnt signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (4)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
chronotype measurement | 1 | 1 | 1 | 0.1 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
chronotype measurement | 1 | 0.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cadherin 19 | VGNC:7313 | 468572 | |||||
Macaque | cadherin 19 | 702726 | ||||||
Mouse | MGI:3588198 | 227485 | ||||||
Rat | RGD:1307169 | 360835 | ||||||
Dog | cadherin 19 | VGNC:39027 | 483948 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cadherin 19 | |||||
Macaque | cadherin 19 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cadherin 19 | |||||
Publication Statistics
PubMed Score 13.36
PubMed score by year
PubTator Score 6.74
PubTator score by year
Related Publications
Text Mined References (12)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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