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Tbio
CDH18
Cadherin-18

Protein Summary
Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274170
  • ENSP00000274170
  • ENSG00000145526
  • ENST00000382275
  • ENSP00000371710
  • ENST00000502796
  • ENSP00000422138
  • ENST00000507958
  • ENSP00000425093

Symbol
  • CDH14
  • CDH14
  • CDH24
  • CDH14L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.75
protein domain
0.73
phenotype
0.72
gene perturbation
0.68
virus perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.2   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 158   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.2   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.951
Data Source:  STRINGDB
CDH9
Tbio
Novelty:  0.06379235
Score:  0.939
Data Source:  STRINGDB
CDH12
Tbio
Novelty:  0.05023568
Score:  0.939
Data Source:  STRINGDB
CDH6
Tbio
Novelty:  0.01278517
Score:  0.937
Data Source:  STRINGDB
CTNNA1
Tbio
Novelty:  0.00925774
Score:  0.935
Data Source:  STRINGDB
CDH24
Tbio
Novelty:  0.41415899
Score:  0.927
Data Source:  STRINGDB
CTNND1
Tbio
Novelty:  0.00335459
Score:  0.923
Data Source:  STRINGDB
CDH17
Tbio
Novelty:  0.00035679
Score:  0.921
Data Source:  STRINGDB
CDH10
Tbio
Novelty:  0.06137544
Score:  0.916
Data Source:  STRINGDB
JUP
Tbio
Novelty:  0.0081803
Score:  0.916
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.2
46.2
migraine with aura
1
1
0
20.6
41.9
age at onset
1
1
0
20.6
41.9
alcohol consumption measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
46.2
migraine with aura
0
20.6
41.9
age at onset
0
20.6
41.9
alcohol consumption measurement
1
38.2
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cadherin 18
VGNC:11876
471585
Macaque
cadherin 18
701472
Mouse
MGI:1344366
320865
Rat
RGD:1305430
310174
Dog
cadherin 18
VGNC:39026
489256
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cadherin 18
Macaque
cadherin 18
Mouse
Rat
Dog
cadherin 18
Publication Statistics
PubMed Score 16.20
PubMed score by year
PubTator Score 5.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title