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Tbio
CDH17
Cadherin-17

Protein Summary
Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing results in mul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000027335
  • ENSP00000027335
  • ENSG00000079112
  • ENST00000450165
  • ENSP00000401468

Symbol
  • HPT1
  • CDH16
  • HPT-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.75
cell type or tissue
0.73
tissue sample
0.7
molecular function
0.63
PubMedID
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2311   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 426   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2311   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 426   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (186)
CTNND1
Tbio
Novelty:  0.00335459
Score:  0.99
Data Source:  STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.988
Data Source:  STRINGDB
CTNNA1
Tbio
Novelty:  0.00925774
Score:  0.958
Data Source:  STRINGDB
JUP
Tbio
Novelty:  0.0081803
Score:  0.954
Data Source:  STRINGDB
CDH1
Tbio
Novelty:  0.00010629
Score:  0.933
Data Source:  STRINGDB
CDH5
Tbio
Novelty:  0.00072649
Score:  0.932
Data Source:  STRINGDB
CDH3
Tbio
Novelty:  0.00295114
Score:  0.929
Data Source:  STRINGDB
CDH2
Tbio
Novelty:  0.00040112
Score:  0.928
Data Source:  STRINGDB
CDH11
Tbio
Novelty:  0.00483005
Score:  0.926
Data Source:  STRINGDB
CDH12
Tbio
Novelty:  0.05023568
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
63.8
systolic blood pressure
2
2
2
55.9
response to diisocyanate
1
1
0
3
35
asthma
1
1
0
3
35
1
1
1
9.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
63.8
systolic blood pressure
2
55.9
response to diisocyanate
0
3
35
asthma
0
3
35
1
9.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cadherin 17
VGNC:6665
464286
Macaque
cadherin 17
698886
Mouse
MGI:1095414
12557
Rat
RGD:619748
117048
Dog
cadherin 17
VGNC:39025
487050
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cadherin 17
Macaque
cadherin 17
Mouse
Rat
Dog
cadherin 17
Publication Statistics
PubMed Score 2311.00
PubMed score by year
PubTator Score 88.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title