Protein Summary
Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333). Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production. (Microbial infection) Serves as a receptor for Listeria monocytogenes; internalin A (InlA) binds to this protein and promotes uptake of the bacteria. This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependen ...more
- ENST00000261769
- ENSP00000261769
- ENSG00000039068
- ENST00000422392
- ENSP00000414946
- CDHE
- UVO
- UVO
- CDHE
- ECAD
- LCAM
- Arc-1
- BCDS1
- CD324
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
hub protein | 1 | ||
chemical | 0.99 | ||
cellular component | 0.94 | ||
protein domain | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9252.5 (req: < 5)
Gene RIFs: 1581 (req: <= 3)
Antibodies: 2688 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9252.5 (req: >= 5)
Gene RIFs: 1581 (req: > 3)
Antibodies: 2688 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (833)
CTNNA3
Novelty: 0.01472452
p_int: 0.999999802
p_ni: 4.4e-8
p_wrong: 1.54e-7
Score: 0.908
Data Source: BioPlex,STRINGDB
CTNND1
Novelty: 0.00335459
p_int: 0.999822516
p_ni: 0.00006434
p_wrong: 0.000113145
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PCDHGC3
Novelty: 0.07203024
p_int: 0.751930881
p_ni: 0.000787222
p_wrong: 0.247281897
Score: 0.187
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (21)
Upstream (18)
Downstream (3)
1 – 5 of 18
Pathways (70)
Reactome (23)
KEGG (13)
PathwayCommons (20)
WikiPathways (14)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Adherens junctions interactions | ||||
Reactome | Apoptosis | ||||
Reactome | Apoptotic cleavage of cell adhesion proteins | ||||
Reactome | Apoptotic cleavage of cellular proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Adherens junctions interactions | ||||
Apoptosis | ||||
Apoptotic cleavage of cell adhesion proteins | ||||
Apoptotic cleavage of cellular proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (51)
Functions (10)
Components (20)
Processes (21)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 4 | 4 | 97.8 | |||||
reticulocyte measurement | 3 | 3 | 3 | 95.3 | |||||
reticulocyte count | 6 | 3 | 6 | 94.3 | |||||
HbA1c measurement | 2 | 3 | 3 | 84.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 82.7 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
red blood cell distribution width | 4 | 97.8 | |||||
reticulocyte measurement | 3 | 95.3 | |||||
reticulocyte count | 6 | 94.3 | |||||
HbA1c measurement | 3 | 84.3 | |||||
mean corpuscular hemoglobin concentration | 1 | 82.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cadherin 1 | VGNC:8961 | 468009 | |||||
Macaque | cadherin 1 | 704387 | ||||||
Mouse | MGI:88354 | 12550 | ||||||
Rat | RGD:69279 | 83502 | ||||||
Dog | cadherin 1 | VGNC:53314 | 442858 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cadherin 1 | |||||
Macaque | cadherin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cadherin 1 | |||||
Publication Statistics
PubMed Score 9252.50
PubMed score by year
PubTator Score 6804.02
PubTator score by year
Related Publications
Text Mined References (1735)
GeneRif Annotations (1581)
Items per page:
0 of 0
PMID | Year | Title |
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