Tbio CDCA8 Borealin

Protein Summary

Description

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]

Uniprot Accession IDs

• Q53HL2
• D3DPT4
• Q53HN1
• Q96AM3
• Q9NVW5

Gene Name

• CDCA8

Ensembl ID

• ENST00000327331
• ENSP00000316121
• ENSG00000134690
• ENST00000373055
• ENSP00000362146

Symbol

• PESCRG3
• BOR
• DasraB
• MESRGP
• BOREALIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.85
cellular component	0.84
transcription factor perturbation	0.84
transcription factor binding site profile	0.81
kinase perturbation	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.16   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 409   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.16   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (344)

Explore Interacting Targets

1 – 10 of 344

• See Interactions on String-DB

BIRC5

Tchem

Novelty:  0.00332112

p_int:  1

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

TRIM44

Tbio

Novelty:  0.00483553

p_int:  0.99999953

p_ni:  3.98e-7

p_wrong:  7.3e-8

Data Source:  BioPlex

MYH3

Tbio

Novelty:  0.00544794

p_int:  0.999569486

p_ni:  0.000409041

p_wrong:  0.000021473

Score:  0.207

Data Source:  BioPlex,STRINGDB

MYH7

Tbio

Novelty:  0.00268092

p_int:  0.999295981

p_ni:  0.000703279

p_wrong:  7.4e-7

Score:  0.189

Data Source:  BioPlex,STRINGDB

VSNL1

Tbio

Novelty:  0.01221371

p_int:  0.998497519

p_ni:  0.001281879

p_wrong:  0.000220602

Score:  0.158

Data Source:  BioPlex,STRINGDB

MYH4

Tbio

Novelty:  0.00556982

p_int:  0.997477594

p_ni:  0.002476473

p_wrong:  0.000045933

Score:  0.19

Data Source:  BioPlex,STRINGDB

CHCHD2

Tbio

Novelty:  0.01615338

p_int:  0.995945436

p_ni:  0.000248317

p_wrong:  0.003806247

Data Source:  BioPlex

ATP4A

Tclin

Family:  Transporter

Novelty:  0.00008783

p_int:  0.994862657

p_ni:  0.000324726

p_wrong:  0.004812617

Score:  0.179

Data Source:  BioPlex,STRINGDB

CAMK2A

Tchem

Family:  Kinase

Novelty:  0.00534906

p_int:  0.99115014

p_ni:  0.008849072

p_wrong:  7.89e-7

Score:  0.169

Data Source:  BioPlex,STRINGDB

CRMP1

Tbio

Family:  Enzyme

Novelty:  0.01998451

p_int:  0.966072801

p_ni:  0.033927199

Score:  0.473

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (22)

Reactome (21)

PathwayCommons (1)

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

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5

1 – 5 of 21

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Reactome	Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle Checkpoints	272 targets	R-HSA-69620
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278

Name	Explore in Pharos	Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	93 targets	R-HSA-141444
Amplification of signal from the kinetochores	93 targets	R-HSA-141424
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle Checkpoints	272 targets	R-HSA-69620
Cell Cycle, Mitotic	495 targets	R-HSA-69278

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Components (11)

Processes (4)

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Items per page:

10

1 – 10 of 11

GO Term	Evidence	Assigned by
chromosome, centromeric region	Inferred from Direct Assay (IDA)	UniProtKB
intercellular bridge	Inferred from Direct Assay (IDA)	HPA
midbody	Inferred from Direct Assay (IDA)	FlyBase
nucleolus	Inferred from Direct Assay (IDA)	HPA
nucleus	Inferred from Direct Assay (IDA)	HPA
protein-containing complex	Inferred from Direct Assay (IDA)	UniProtKB
chromosome passenger complex	Inferred from Physical Interaction (IPI)	UniProtKB
spindle midzone	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cytosol	Traceable Author Statement (TAS)	Reactome
nucleoplasm	Traceable Author Statement (TAS)	Reactome

Disease Associations ()

No disease associations found

GWAS Traits (10)

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1 – 5 of 10

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
corneal topography	EFO_0004345	4	1	4		87.2
intraocular pressure measurement	EFO_0004695	2	1	2		53.3
mathematical ability	EFO_0004875	3	2	3		53.2
Malignant epithelial tumor of ovary	Orphanet_398934	1	1	0	1.1	50.6
ovarian carcinoma	EFO_0001075	1	1	0	1.1	35

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 10

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
corneal topography	EFO_0004345	4		87.2
intraocular pressure measurement	EFO_0004695	2		53.3
mathematical ability	EFO_0004875	3		53.2
Malignant epithelial tumor of ovary	Orphanet_398934	0	1.1	50.6
ovarian carcinoma	EFO_0001075	0	1.1	35

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Cell cycle
Cell division
Centromere
Chromosome
Complete proteome
Cytoplasm
Cytoskeleton
Isopeptide bond
Mitosis

GWAS Trait Find Similar Targets

No Header	No Header
balding measurement
corneal topography
endometrial carcinoma
eosinophil count
eosinophil percentage of leukocytes
intraocular pressure measurement
Malignant epithelial tumor of ovary
mathematical ability
ovarian carcinoma
self reported educational attainment

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cellular phenotype
embryo phenotype
homeostasis/metabolism phenotype
integument phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cell division cycle associated 8	VGNC:473	456762
Macaque	cell division cycle associated 8		719808
Mouse	cell division cycle associated 8	MGI:1196274	52276
Rat	cell division cycle associated 8	RGD:1566306	500545
Dog	cell division cycle associated 8	VGNC:39017	608164

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cell division cycle associated 8
Macaque	cell division cycle associated 8
Mouse	cell division cycle associated 8
Rat	cell division cycle associated 8
Dog	cell division cycle associated 8

Publication Statistics

PubMed Score 65.16

PubMed score by year

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PubTator Score 52.97

PubTator score by year

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Related Publications

Text Mined References (46)

GeneRif Annotations (21)

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PMID	Year	Title