Protein Summary
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]
- ENST00000327331
- ENSP00000316121
- ENSG00000134690
- ENST00000373055
- ENSP00000362146
- PESCRG3
- BOR
- DasraB
- MESRGP
- BOREALIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
co-expressed gene | 0.85 | ||
cellular component | 0.84 | ||
transcription factor perturbation | 0.84 | ||
transcription factor binding site profile | 0.81 | ||
kinase perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.16 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 409 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 65.16 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 409 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (344)
MYH3
Novelty: 0.00544794
p_int: 0.999569486
p_ni: 0.000409041
p_wrong: 0.000021473
Score: 0.207
Data Source: BioPlex,STRINGDB
MYH7
Novelty: 0.00268092
p_int: 0.999295981
p_ni: 0.000703279
p_wrong: 7.4e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
VSNL1
Novelty: 0.01221371
p_int: 0.998497519
p_ni: 0.001281879
p_wrong: 0.000220602
Score: 0.158
Data Source: BioPlex,STRINGDB
MYH4
Novelty: 0.00556982
p_int: 0.997477594
p_ni: 0.002476473
p_wrong: 0.000045933
Score: 0.19
Data Source: BioPlex,STRINGDB
CHCHD2
Novelty: 0.01615338
p_int: 0.995945436
p_ni: 0.000248317
p_wrong: 0.003806247
Data Source: BioPlex
ATP4A
Family: Transporter
Novelty: 0.00008783
p_int: 0.994862657
p_ni: 0.000324726
p_wrong: 0.004812617
Score: 0.179
Data Source: BioPlex,STRINGDB
CAMK2A
Family: Kinase
Novelty: 0.00534906
p_int: 0.99115014
p_ni: 0.008849072
p_wrong: 7.89e-7
Score: 0.169
Data Source: BioPlex,STRINGDB
CRMP1
Family: Enzyme
Novelty: 0.01998451
p_int: 0.966072801
p_ni: 0.033927199
Score: 0.473
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (22)
Reactome (21)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Reactome | Amplification of signal from the kinetochores | ||||
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Reactome | Cell Cycle, Mitotic | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal | ||||
Amplification of signal from the kinetochores | ||||
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
Cell Cycle, Mitotic | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Components (11)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | FlyBase | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
corneal topography | 4 | 1 | 4 | 87.2 | |||||
intraocular pressure measurement | 2 | 1 | 2 | 53.3 | |||||
mathematical ability | 3 | 2 | 3 | 53.2 | |||||
1 | 1 | 0 | 1.1 | 50.6 | |||||
1 | 1 | 0 | 1.1 | 35 | |||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
corneal topography | 4 | 87.2 | |||||
intraocular pressure measurement | 2 | 53.3 | |||||
mathematical ability | 3 | 53.2 | |||||
0 | 1.1 | 50.6 | |||||
0 | 1.1 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cell division cycle associated 8 | VGNC:473 | 456762 | |||||
Macaque | cell division cycle associated 8 | 719808 | ||||||
Mouse | MGI:1196274 | 52276 | ||||||
Rat | RGD:1566306 | 500545 | ||||||
Dog | cell division cycle associated 8 | VGNC:39017 | 608164 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cell division cycle associated 8 | |||||
Macaque | cell division cycle associated 8 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cell division cycle associated 8 | |||||
Publication Statistics
PubMed Score 65.16
PubMed score by year
PubTator Score 52.97
PubTator score by year
Related Publications
Text Mined References (46)
GeneRif Annotations (21)
Items per page:
0 of 0
PMID | Year | Title |
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