Tbio CDCA4 Cell division cycle-associated protein 4

Protein Summary

Description

May participate in the regulation of cell proliferation through the E2F/RB pathway. May be involved in molecular regulation of hematopoietic stem cells and progenitor cell lineage commitment and differentiation (By similarity). This gene encodes a protein that belongs to the E2F family of transcription factors. This protein regulates E2F-dependent transcriptional activation and cell proliferation, mainly through the E2F/retinoblastoma protein pathway. It also functions in the regulation of JUN oncogene expression. This protein shows distinctive nuclear-mitotic apparatus distribution, it is involved in spindle organization from prometaphase, and may also play a role as a midzone factor involved in chromosome segregation or cytokinesis. Two alternatively spliced transcript variants encoding the same protein have been noted for this gene. Two pseudogenes have also been identified on chromosome 1. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• Q9BXL8
• Q8TB18
• Q9NWK7

Gene Name

• CDCA4

Ensembl ID

• ENST00000336219
• ENSP00000337226
• ENSG00000170779
• ENST00000392590
• ENSP00000376369

Symbol

• HEPP
• HEPP
• SEI-3/HEPP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor binding site profile	0.84
disease perturbation	0.83
transcription factor perturbation	0.8
microRNA	0.79

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Cell Division Cycle-associated Protein 4

DTO Classes

Protein / Transcription Factor / Cell Division Cycle-associated Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.85   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 186   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.85   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0