You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CDCA2
Cell division cycle-associated protein 2

Protein Summary
Description
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330560
  • ENSP00000328228
  • ENSG00000184661

Symbol
  • PPP1R81
  • Repo-Man
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.77
transcription factor perturbation
0.68
histone modification site profile
0.6
kinase perturbation
0.6
PubMedID
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.43   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.43   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (169)
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999999987
p_ni:  1.2e-8
p_wrong:  1e-9
Score:  0.489
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999999912
p_ni:  6.1e-8
p_wrong:  2.6e-8
Score:  0.32
Data Source:  BioPlex,STRINGDB
KPNA2
Tbio
Novelty:  0.00506958
p_int:  0.999995601
p_ni:  0.000004399
Score:  0.82
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.999987557
p_ni:  0.000012443
Data Source:  BioPlex
NUP50
Tbio
Novelty:  0.03424725
p_int:  0.999668048
p_ni:  0.000331902
p_wrong:  4.9e-8
Score:  0.611
Data Source:  BioPlex,STRINGDB
RAN
Tchem
Family:  Enzyme
Novelty:  0.00160888
p_int:  0.999148146
p_ni:  0.000851854
Score:  0.209
Data Source:  BioPlex,STRINGDB
IER2
Tbio
Novelty:  0.03864806
p_int:  0.997239258
p_ni:  0.002712398
p_wrong:  0.000048344
Score:  0.179
Data Source:  BioPlex,STRINGDB
TCEAL1
Tbio
Novelty:  0.02210924
p_int:  0.995735639
p_ni:  0.004264191
p_wrong:  1.69e-7
Data Source:  BioPlex
B2M
Tbio
Novelty:  0.00011248
p_int:  0.976364702
p_ni:  0.021044365
p_wrong:  0.002590932
Score:  0.183
Data Source:  BioPlex,STRINGDB
PBK
Tchem
Family:  Kinase
Novelty:  0.00278659
Score:  0.907
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
76.7
reticulocyte measurement
3
2
3
70.4
testosterone measurement
3
3
3
66.8
lymphocyte count
2
1
2
64.4
red blood cell distribution width
2
2
2
58.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
76.7
reticulocyte measurement
3
70.4
testosterone measurement
3
66.8
lymphocyte count
2
64.4
red blood cell distribution width
2
58.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell division cycle associated 2
VGNC:906
464066
Macaque
cell division cycle associated 2
711581
Mouse
MGI:1919787
108912
Rat
RGD:1311003
305984
Dog
cell division cycle associated 2
VGNC:39012
477377
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell division cycle associated 2
Macaque
cell division cycle associated 2
Mouse
Rat
Dog
cell division cycle associated 2
Publication Statistics
PubMed Score 31.43
PubMed score by year
PubTator Score 16.35
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title