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Tbio
CDC6
Cell division control protein 6 homolog

Protein Summary
Description
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated. The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000209728
  • ENSP00000209728
  • ENSG00000094804
  • ENST00000647931
  • ENSP00000497975
  • ENST00000649662
  • ENSP00000497345

Symbol
  • CDC18L
  • CDC18L
  • HsCDC6
  • MGORS5
  • HsCDC18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
transcription factor perturbation
0.88
biological process
0.86
molecular function
0.86
hub protein
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 532.87   (req: < 5)
Gene RIFs: 76   (req: <= 3)
Antibodies: 711   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 532.87   (req: >= 5)
Gene RIFs: 76   (req: > 3)
Antibodies: 711   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (497)
CCNF
Tbio
Novelty:  0.01288697
p_int:  0.999993886
p_ni:  0.000004406
p_wrong:  0.000001707
Score:  0.864
Data Source:  BioPlex,STRINGDB
LAMP2
Tbio
Novelty:  0.00168009
p_int:  0.999480976
p_ni:  0.000519024
Data Source:  BioPlex
ISLR
Tbio
Novelty:  0.02936208
p_int:  0.999465872
p_ni:  0.000534128
Data Source:  BioPlex
IL20RA
Tbio
Novelty:  0.02416816
p_int:  0.993525629
p_ni:  0.006474369
p_wrong:  2e-9
Data Source:  BioPlex
TNFRSF1A
Tchem
Novelty:  0.00037847
p_int:  0.993466408
p_ni:  0.006533583
p_wrong:  9e-9
Data Source:  BioPlex
FAM131B
Tdark
Novelty:  0.3424123
p_int:  0.992070232
p_ni:  0.007929767
p_wrong:  1e-9
Data Source:  BioPlex
PROZ
Tbio
Family:  Enzyme
Novelty:  0.05629679
p_int:  0.990579956
p_ni:  0.009420032
p_wrong:  1.2e-8
Data Source:  BioPlex
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.983170843
p_ni:  0.016789325
p_wrong:  0.000039832
Data Source:  BioPlex
TIGIT
Tbio
Novelty:  0.0064542
p_int:  0.957965549
p_ni:  0.042026228
p_wrong:  0.000008223
Data Source:  BioPlex
PCDHB11
Tdark
Novelty:  0.80480462
p_int:  0.948646701
p_ni:  0.05135329
p_wrong:  9e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (27)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the pre-replicative complex
Reactome
CDC6 association with the ORC:origin complex
Reactome
CDK-mediated phosphorylation and removal of Cdc6
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Assembly of the pre-replicative complex
CDC6 association with the ORC:origin complex
CDK-mediated phosphorylation and removal of Cdc6
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
4
54.9
response to cetuximab
1
1
0
4
54.9
1
1
0
4
54.9
high density lipoprotein cholesterol measurement
1
1
1
47.2
BMI-adjusted hip circumference
1
1
1
44.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
4
54.9
response to cetuximab
0
4
54.9
0
4
54.9
high density lipoprotein cholesterol measurement
1
47.2
BMI-adjusted hip circumference
1
44.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 6
VGNC:9181
468234
Macaque
cell division cycle 6
700081
Mouse
MGI:1345150
23834
Rat
RGD:1309157
360621
Dog
cell division cycle 6
VGNC:39009
480527
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cell division cycle 6
Macaque
cell division cycle 6
Mouse
Rat
Dog
cell division cycle 6
Publication Statistics
PubMed Score 532.87
PubMed score by year
PubTator Score 179.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title