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Tdark
CDC42EP4
Cdc42 effector protein 4

Protein Summary
Description
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335793
  • ENSP00000338258
  • ENSG00000179604
  • ENST00000439510
  • ENSP00000404270

Symbol
  • BORG4
  • CEP4
  • CEP4
  • BORG4
  • KAIA1777
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.95
kinase perturbation
0.93
virus perturbation
0.85
PubMedID
0.8
protein complex
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.6   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.6   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
SEPT10
Tbio
Novelty:  0.14834834
p_int:  0.99999898
p_ni:  0.00000102
Score:  0.876
Data Source:  BioPlex,STRINGDB
SEPT3
Tbio
Novelty:  0.008513
p_int:  0.999995839
p_ni:  0.000004161
Score:  0.877
Data Source:  BioPlex,STRINGDB
SEPT8
Tbio
Novelty:  0.01431499
p_int:  0.999966481
p_ni:  0.000033519
Score:  0.866
Data Source:  BioPlex,STRINGDB
SEPT5
Tbio
Novelty:  0.01670991
p_int:  0.999916103
p_ni:  0.000083896
p_wrong:  1e-9
Score:  0.9
Data Source:  BioPlex,STRINGDB
SEPT2
Tbio
Novelty:  0.01047916
p_int:  0.999800945
p_ni:  0.000199055
Score:  0.895
Data Source:  BioPlex,STRINGDB
RTN4IP1
Tbio
Family:  Enzyme
Novelty:  0.01274213
p_int:  0.999219926
p_ni:  0.000780065
p_wrong:  9e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
SEPT6
Tbio
Novelty:  0.00885503
p_int:  0.998415478
p_ni:  0.001584522
Score:  0.914
Data Source:  BioPlex,STRINGDB
SEPT7
Tbio
Novelty:  0.00554708
p_int:  0.998318223
p_ni:  0.001681777
Score:  0.911
Data Source:  BioPlex,STRINGDB
SEPT11
Tbio
Novelty:  0.05272429
p_int:  0.997501813
p_ni:  0.002498187
Score:  0.896
Data Source:  BioPlex,STRINGDB
SEPT9
Tchem
Novelty:  0.00407266
p_int:  0.996182152
p_ni:  0.003817848
Score:  0.9
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
75.7
mean reticulocyte volume
1
1
1
74.6
mean corpuscular volume
1
1
1
71.9
mean corpuscular hemoglobin concentration
1
1
1
64.9
reticulocyte count
2
2
2
57.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
75.7
mean reticulocyte volume
1
74.6
mean corpuscular volume
1
71.9
mean corpuscular hemoglobin concentration
1
64.9
reticulocyte count
2
57.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
CDC42 effector protein 4
696227
Mouse
MGI:1929760
56699
Rat
RGD:1311567
303653
Dog
CDC42 effector protein 4
VGNC:39003
475907
Horse
CDC42 effector protein 4
VGNC:16300
100061186
Species
Name
OMA
EggNOG
Inparanoid
Macaque
CDC42 effector protein 4
Mouse
Rat
Dog
CDC42 effector protein 4
Horse
CDC42 effector protein 4
Publication Statistics
PubMed Score 4.60
PubMed score by year
PubTator Score 4.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title