You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CDC42
Cell division control protein 42 homolog

Protein Summary
Description
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups. The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migratio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315554
  • ENSP00000314458
  • ENSG00000070831
  • ENST00000344548
  • ENSP00000341072
  • ENST00000400259
  • ENSP00000383118

Symbol
  • TKS
  • G25K
  • CDC42Hs
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
interacting protein
1
molecular function
0.99
pathway
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3087.25   (req: < 5)
Gene RIFs: 346   (req: <= 3)
Antibodies: 475   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3087.25   (req: >= 5)
Gene RIFs: 346   (req: > 3)
Antibodies: 475   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 64
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (926)
MYL6
Tbio
Novelty:  0.00594485
p_int:  0.992718955
p_ni:  0.007281046
Score:  0.946
Data Source:  BioPlex,STRINGDB
CDC42SE1
Tdark
Novelty:  0.02176417
p_int:  0.980589644
p_ni:  0.019410356
Score:  0.647
Data Source:  BioPlex,STRINGDB
CDC42SE2
Tbio
Novelty:  0.04549938
p_int:  0.955980437
p_ni:  0.044019563
Score:  0.765
Data Source:  BioPlex,STRINGDB
IQGAP3
Tbio
Family:  Enzyme
Novelty:  0.05874747
p_int:  0.844916553
p_ni:  0.155083448
Score:  0.969
Data Source:  BioPlex,Reactome,STRINGDB
WAS
Tbio
Novelty:  0.00087362
Score:  0.999
Data Source:  Reactome,STRINGDB
PAK1
Tchem
Family:  Kinase
Novelty:  0.00411227
Score:  0.999
Data Source:  Reactome,STRINGDB
BAIAP2
Tbio
Novelty:  0.00949996
Score:  0.999
Data Source:  STRINGDB
WASL
Tbio
Novelty:  0.0029314
Score:  0.999
Data Source:  Reactome,STRINGDB
PARD6A
Tbio
Novelty:  0.05667035
Score:  0.998
Data Source:  STRINGDB
PARD6B
Tbio
Novelty:  0.08495161
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets (8)
Explore Nearest Tclin Targets
1 – 5 of 5
PIK3CA
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  21
more:  17 more common pathways
PIK3CD
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  21
more:  17 more common pathways
SRC
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  16
more:  12 more common pathways
KDR
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  6
more:  2 more common pathways
Pathways (149)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 46
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
CD28 co-stimulation
Reactome
CD28 dependent Vav1 pathway
Reactome
Costimulation by the CD28 family
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
CD28 co-stimulation
CD28 dependent Vav1 pathway
Costimulation by the CD28 family
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (87)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
AgBase
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
7
10
98.6
bone density
8
7
11
93.5
4
3
0
1.1
88.8
BMI-adjusted hip circumference
3
9
9
82.2
BMI-adjusted waist-hip ratio
2
2
2
80.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
10
98.6
bone density
11
93.5
0
1.1
88.8
BMI-adjusted hip circumference
9
82.2
BMI-adjusted waist-hip ratio
2
80.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cell division cycle 42
707637
Mouse
MGI:106211
12540
Rat
RGD:71043
64465
Dog
cell division cycle 42
403934
Horse
cell division cycle 42
100058188
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cell division cycle 42
Mouse
Rat
Dog
cell division cycle 42
Horse
cell division cycle 42
Publication Statistics
PubMed Score 3087.25
PubMed score by year
PubTator Score 1457.96
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title