Tbio CDC37L1 Hsp90 co-chaperone Cdc37-like 1

Protein Summary

Description

Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90. CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q7L3B6
• B1AL70
• Q9NWS3
• Q9NX16

Gene Name

• CDC37L1

Ensembl ID

• ENST00000381854
• ENSP00000371278
• ENSG00000106993

Symbol

• CDC37B
• HARC
• HARC
• CDC37B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
histone modification site profile	0.89
transcription factor binding site profile	0.85
disease perturbation	0.74
kinase perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Hsp90 Co-chaperone Cdc37-like 1

Protein / Chaperone / Hsp90 Co-chaperone Cdc37-like 1

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Activator / Hsp90 Co-chaperone Cdc37-like 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.32   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 176   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.32   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0