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Tchem
CDC25C
M-phase inducer phosphatase 3

Protein Summary
Description
Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity. This gene encodes a conserved protein that plays a key role in the regulation of cell division. The encoded protein directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It also suppresses p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323760
  • ENSP00000321656
  • ENSG00000158402
  • ENST00000348983
  • ENSP00000345205
  • ENST00000415130
  • ENSP00000392631
  • ENST00000513970
  • ENSP00000424795
  • ENST00000514555
  • ENSP00000425470

Symbol
  • CDC25
  • PPP1R60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
1
hub protein
0.98
transcription factor perturbation
0.91
biological term
0.85
chemical
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 407.62   (req: < 5)
Gene RIFs: 81   (req: <= 3)
Antibodies: 1007   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 407.62   (req: >= 5)
Gene RIFs: 81   (req: > 3)
Antibodies: 1007   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0