Tbio CDC23 Cell division cycle protein 23 homolog

Protein Summary

Description

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UJX2
• A8K6E5
• B4E3A2
• B7WP05
• D3DQB7
• O75433
• Q53FN2
• Q9BS73

Gene Name

• CDC23

Ensembl ID

• ENST00000394884
• ENSP00000378348
• ENSG00000094880
• ENST00000394886
• ENSP00000378350

Symbol

• ANAPC8
• APC8
• CUT23
• ANAPC8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
biological process	0.96
virus perturbation	0.96
histone modification site profile	0.88
disease perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.77   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 267   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.77   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (478)

Explore Interacting Targets

1 – 10 of 478

• See Interactions on String-DB

ANAPC13

Tbio

Family:  Enzyme

Novelty:  0.06125489

p_int:  0.999998592

p_ni:  0.000001407

p_wrong:  1e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

CDC26

Tbio

Family:  Enzyme

Novelty:  0.07456358

p_int:  0.999997546

p_ni:  0.000002454

Score:  0.999

Data Source:  BioPlex,STRINGDB

ANAPC5

Tbio

Family:  Enzyme

Novelty:  0.02102572

p_int:  0.99999748

p_ni:  0.000002516

p_wrong:  4e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

CDC16

Tbio

Novelty:  0.00916715

p_int:  0.999996688

p_ni:  0.000003312

Score:  0.999

Data Source:  BioPlex,STRINGDB

ANAPC16

Tdark

Family:  Enzyme

Novelty:  0.06353035

p_int:  0.999991546

p_ni:  0.000008453

p_wrong:  1e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

C16orf87

Tdark

Novelty:  5.71664261

p_int:  0.999981592

p_ni:  0.000018405

p_wrong:  3e-9

Score:  0.321

Data Source:  BioPlex,STRINGDB

MAGIX

Tdark

Novelty:  0.38577176

p_int:  0.999922343

p_ni:  0.000077657

Score:  0.155

Data Source:  BioPlex,STRINGDB

FZR1

Tbio

Novelty:  0.01599606

p_int:  0.998477496

p_ni:  0.001522504

Score:  0.999

Data Source:  BioPlex,STRINGDB

PENK

Tbio

Novelty:  0.00074167

p_int:  0.998173061

p_ni:  0.001826937

p_wrong:  1e-9

Score:  0.204

Data Source:  BioPlex,STRINGDB

SCGN

Tbio

Novelty:  0.01434518

p_int:  0.997060247

p_ni:  0.002939752

p_wrong:  2e-9

Data Source:  BioPlex

Nearest Tclin Targets (3)

Explore Nearest Tclin Targets

Upstream (3)

1 – 3 of 3

CALM1

Tclin

Family:  Other

KEGG Distance:  4

Common Pathways:  1

1: Oocyte meiosis

CALM2

Tclin

Family:  Other

KEGG Distance:  4

Common Pathways:  1

1: Oocyte meiosis

CALM3

Tclin

Family:  Other

KEGG Distance:  4

Common Pathways:  1

1: Oocyte meiosis

Pathways (72)

Reactome (37)

KEGG (5)

PathwayCommons (1)

UniProt (1)

WikiPathways (28)

APC-Cdc20 mediated degradation of Nek2A (R-HSA-179409)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	APC-Cdc20 mediated degradation of Nek2A	25 targets	R-HSA-179409
Reactome	APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
Reactome	APC/C:Cdc20 mediated degradation of Cyclin B	23 targets	R-HSA-174048
Reactome	APC/C:Cdc20 mediated degradation of Securin	68 targets	R-HSA-174154
Reactome	APC/C:Cdc20 mediated degradation of mitotic proteins	76 targets	R-HSA-176409

Name	Explore in Pharos	Explore in Source
APC-Cdc20 mediated degradation of Nek2A	25 targets	R-HSA-179409
APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
APC/C:Cdc20 mediated degradation of Cyclin B	23 targets	R-HSA-174048
APC/C:Cdc20 mediated degradation of Securin	68 targets	R-HSA-174154
APC/C:Cdc20 mediated degradation of mitotic proteins	76 targets	R-HSA-176409

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (1)

Components (4)

Processes (10)

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1 – 1 of 1

GO Term	Evidence	Assigned by
ubiquitin-protein transferase activity	Traceable Author Statement (TAS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (6)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
atrial fibrillation	EFO_0000275	1	1	0	1.1	34.9
self reported educational attainment	EFO_0004784	1	1	1		30.2
mathematical ability	EFO_0004875	1	1	1		30.2
type II diabetes mellitus	EFO_0001360	1	1	1		3.9
Eczema	HP_0000964	1	1	0	1	2.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
atrial fibrillation	EFO_0000275	0	1.1	34.9
self reported educational attainment	EFO_0004784	1		30.2
mathematical ability	EFO_0004875	1		30.2
type II diabetes mellitus	EFO_0001360	1		3.9
Eczema	HP_0000964	0	1	2.1

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Cell cycle
Cell division
Complete proteome
Isopeptide bond
Mitosis
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
allergic rhinitis
atrial fibrillation
Eczema
mathematical ability
self reported educational attainment
type II diabetes mellitus

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cell division cycle 23	VGNC:11875	462092
Macaque	cell division cycle 23		714000
Mouse	CDC23 cell division cycle 23	MGI:1098815	52563
Rat	cell division cycle 23	RGD:1304819	291689
Dog	cell division cycle 23	VGNC:51703	481526

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cell division cycle 23
Macaque	cell division cycle 23
Mouse	CDC23 cell division cycle 23
Rat	cell division cycle 23
Dog	cell division cycle 23

Publication Statistics

PubMed Score 59.77

PubMed score by year

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PubTator Score 14.01

PubTator score by year

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Related Publications

Text Mined References (43)

GeneRif Annotations (4)

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PMID	Year	Title