Tbio CDC16 Cell division cycle protein 16 homolog

Protein Summary

Description

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• Q13042
• A2A365
• Q5T8C8
• Q7Z651
• Q96AE6
• Q9Y564

Gene Name

• CDC16

Ensembl ID

• ENST00000252457
• ENSP00000252457
• ENSG00000130177
• ENST00000356221
• ENSP00000348554
• ENST00000360383
• ENSP00000353549
• ENST00000375308
• ENSP00000364457
• ENST00000375310
• ENSP00000364459

Symbol

• ANAPC6
• APC6
• CUT9
• ANAPC6
• CDC16Hs

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.98
biological process	0.94
disease perturbation	0.93
cellular component	0.91
kinase perturbation	0.91

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.69   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 382   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.69   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (561)

Explore Interacting Targets

1 – 10 of 561

• See Interactions on String-DB

ANAPC13

Tbio

Family:  Enzyme

Novelty:  0.06125489

p_int:  0.999999852

p_ni:  1.45e-7

p_wrong:  3e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

ANAPC2

Tbio

Family:  Enzyme

Novelty:  0.19812984

p_int:  0.99999971

p_ni:  2.89e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

C16orf87

Tdark

Novelty:  5.71664261

p_int:  0.999999263

p_ni:  7.37e-7

Score:  0.499

Data Source:  BioPlex,STRINGDB

CDC26

Tbio

Family:  Enzyme

Novelty:  0.07456358

p_int:  0.999999157

p_ni:  8.43e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

ANAPC4

Tbio

Family:  Enzyme

Novelty:  0.28937094

p_int:  0.999998986

p_ni:  0.000001014

Score:  0.999

Data Source:  BioPlex,STRINGDB

KIAA0586

Tbio

Novelty:  0.0346398

p_int:  0.999997849

p_ni:  0.000002145

p_wrong:  5e-9

Data Source:  BioPlex

CDC23

Tbio

Novelty:  0.0168525

p_int:  0.999996688

p_ni:  0.000003312

Score:  0.999

Data Source:  BioPlex,STRINGDB

ANAPC5

Tbio

Family:  Enzyme

Novelty:  0.02102572

p_int:  0.999996427

p_ni:  0.000003573

Score:  0.999

Data Source:  BioPlex,STRINGDB

CEP295

Tbio

Novelty:  0.22993687

p_int:  0.999990286

p_ni:  0.000009706

p_wrong:  8e-9

Data Source:  BioPlex

ANAPC1

Tbio

Family:  Enzyme

Novelty:  0.0521845

p_int:  0.999978957

p_ni:  0.000021043

Score:  0.999

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (3)

Explore Nearest Tclin Targets

Upstream (3)

1 – 3 of 3

CALM2

Tclin

Family:  Other

KEGG Distance:  4

Common Pathways:  1

1: Oocyte meiosis

CALM3

Tclin

Family:  Other

KEGG Distance:  4

Common Pathways:  1

1: Oocyte meiosis

CALM1

Tclin

Family:  Other

KEGG Distance:  4

Common Pathways:  1

1: Oocyte meiosis

Pathways (70)

Reactome (37)

KEGG (5)

PathwayCommons (1)

UniProt (1)

WikiPathways (26)

APC-Cdc20 mediated degradation of Nek2A (R-HSA-179409)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	APC-Cdc20 mediated degradation of Nek2A	25 targets	R-HSA-179409
Reactome	APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
Reactome	APC/C:Cdc20 mediated degradation of Cyclin B	23 targets	R-HSA-174048
Reactome	APC/C:Cdc20 mediated degradation of Securin	68 targets	R-HSA-174154
Reactome	APC/C:Cdc20 mediated degradation of mitotic proteins	76 targets	R-HSA-176409

Name	Explore in Pharos	Explore in Source
APC-Cdc20 mediated degradation of Nek2A	25 targets	R-HSA-179409
APC/C-mediated degradation of cell cycle proteins	87 targets	R-HSA-174143
APC/C:Cdc20 mediated degradation of Cyclin B	23 targets	R-HSA-174048
APC/C:Cdc20 mediated degradation of Securin	68 targets	R-HSA-174154
APC/C:Cdc20 mediated degradation of mitotic proteins	76 targets	R-HSA-176409

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Components (6)

Processes (7)

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1 – 6 of 6

GO Term	Evidence	Assigned by
anaphase-promoting complex	Inferred from Direct Assay (IDA)	UniProtKB
centrosome	Inferred from Direct Assay (IDA)	MGI
cytoplasm	Inferred from Direct Assay (IDA)	LIFEdb
cytosol	Traceable Author Statement (TAS)	Reactome
nucleoplasm	Traceable Author Statement (TAS)	Reactome
spindle	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (12)

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1 – 5 of 12

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	3	2	3		94.4
sex hormone-binding globulin measurement	EFO_0004696	3	2	3		82
eosinophil count	EFO_0004842	2	2	2		78.2
eosinophil percentage of leukocytes	EFO_0007991	1	1	1		68.3
leukocyte count	EFO_0004308	1	1	1		61.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte count	EFO_0004587	3		94.4
sex hormone-binding globulin measurement	EFO_0004696	3		82
eosinophil count	EFO_0004842	2		78.2
eosinophil percentage of leukocytes	EFO_0007991	1		68.3
leukocyte count	EFO_0004308	1		61.4

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell cycle
Cell division
Complete proteome
Cytoplasm
Cytoskeleton
Mitosis
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
body height
eosinophil count
eosinophil percentage of leukocytes
leukocyte count
lymphocyte count
lymphocyte percentage of leukocytes
monocyte count
monocyte percentage of leukocytes
neutrophil percentage of leukocytes

IDG Resources

No IDG generated resources found

Orthologs (15)

1 – 5 of 15

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cell division cycle 16	VGNC:51842	452688
Macaque	cell division cycle 16		699089
Mouse	CDC16 cell division cycle 16	MGI:1917207	69957
Rat	cell division cycle 16	RGD:1305076	290875
Dog	cell division cycle 16		607100

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cell division cycle 16
Macaque	cell division cycle 16
Mouse	CDC16 cell division cycle 16
Rat	cell division cycle 16
Dog	cell division cycle 16

Publication Statistics

PubMed Score 93.69

PubMed score by year

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PubTator Score 38.19

PubTator score by year

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Related Publications

Text Mined References (42)

GeneRif Annotations (5)

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PMID	Year	Title