Protein Summary
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 273.21 (req: < 5)
Gene RIFs: 64 (req: <= 3)
Antibodies: 290 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 273.21 (req: >= 5)
Gene RIFs: 64 (req: > 3)
Antibodies: 290 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 14
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (14)
Protein-Protein Interactions (202)
MPP2
Novelty: 0.0372293
p_int: 0.999999553
p_ni: 4.47e-7
Score: 0.714
Data Source: BioPlex,STRINGDB
MTMR9
Novelty: 0.09702778
p_int: 0.999845015
p_ni: 0.000154566
p_wrong: 4.19e-7
Score: 0.747
Data Source: BioPlex,STRINGDB
MPP6
Novelty: 0.08883057
p_int: 0.999773731
p_ni: 0.000226269
Score: 0.592
Data Source: BioPlex,STRINGDB
CDKN2C
Family: Enzyme
Novelty: 0.00806886
p_int: 0.998779624
p_ni: 0.001214276
p_wrong: 0.0000061
Score: 0.638
Data Source: BioPlex,STRINGDB
APBA3
Novelty: 0.05059532
p_int: 0.995763469
p_ni: 0.00423653
p_wrong: 1e-9
Score: 0.191
Data Source: BioPlex,STRINGDB
LIN7A
Novelty: 0.0202389
p_int: 0.994045364
p_ni: 0.005954604
p_wrong: 3.3e-8
Score: 0.818
Data Source: BioPlex,STRINGDB
MTMR6
Family: Enzyme
Novelty: 0.13067072
p_int: 0.993867425
p_ni: 0.006132531
p_wrong: 4.4e-8
Score: 0.552
Data Source: BioPlex,STRINGDB
RNF181
Family: Enzyme
Novelty: 0.27482636
p_int: 0.94990942
p_ni: 0.029917178
p_wrong: 0.020173402
Score: 0.19
Data Source: BioPlex,STRINGDB
PYM1
Novelty: 0.04117785
p_int: 0.873968073
p_ni: 0.126031815
p_wrong: 1.12e-7
Score: 0.588
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (4)
Upstream (2)
Downstream (2)
1 – 2 of 2
Pathways (17)
Reactome (7)
KEGG (3)
PathwayCommons (5)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Metabolism | ||||
Metabolism of nucleotides | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (4)
Components (5)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean reticulocyte volume | 1 | 1 | 1 | 84.6 | |||||
mean corpuscular volume | 1 | 1 | 1 | 83.5 | |||||
alkaline phosphatase measurement | 2 | 2 | 1 | 8.4 | 76.1 | ||||
apolipoprotein A 1 measurement | 1 | 1 | 1 | 71.5 | |||||
lymphocyte count | 2 | 2 | 2 | 70.2 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean reticulocyte volume | 1 | 84.6 | |||||
mean corpuscular volume | 1 | 83.5 | |||||
alkaline phosphatase measurement | 1 | 8.4 | 76.1 | ||||
apolipoprotein A 1 measurement | 1 | 71.5 | |||||
lymphocyte count | 2 | 70.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cytidine deaminase | VGNC:470 | 744046 | |||||
Mouse | MGI:1919519 | 72269 | ||||||
Rat | RGD:6501229 | 100909857 | ||||||
Dog | cytidine deaminase | VGNC:38983 | 487393 | |||||
Horse | cytidine deaminase | VGNC:16284 | 100058403 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cytidine deaminase | |||||
Mouse | ||||||
Rat | ||||||
Dog | cytidine deaminase | |||||
Horse | cytidine deaminase | |||||
Publication Statistics
PubMed Score 273.21
PubMed score by year
PubTator Score 1055.32
PubTator score by year
Related Publications
Text Mined References (89)
GeneRif Annotations (64)
Items per page:
0 of 0
PMID | Year | Title |
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