Tbio CD99 CD99 antigen

Protein Summary

Description

Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity). The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• P14209
• A6NIW1
• O00518
• Q6ICV7

Gene Name

• CD99

Ensembl ID

• ENST00000381187
• ENSP00000370582
• ENSG00000002586
• ENST00000381192
• ENSP00000370588
• ENST00000482405
• ENSP00000494027
• ENST00000611428
• ENSP00000479999
• ENST00000623253
• ENSP00000485545

Symbol

• MIC2
• MIC2X
• MIC2Y
• MIC2
• HBA71
• MIC2X
• MIC2Y
• MSK5X

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule perturbation	0.85
transcription factor perturbation	0.84
biological term	0.72
cellular component	0.67
tissue sample	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.61   (req: < 5)

Gene RIFs: 91   (req: <= 3)

Antibodies: 1542   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 548.61   (req: >= 5)

Gene RIFs: 91   (req: > 3)

Antibodies: 1542   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0