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Tbio
CD96
T-cell surface protein tactile

Protein Summary
Description
May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation. The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283285
  • ENSP00000283285
  • ENSG00000153283
  • ENST00000352690
  • ENSP00000342040

Symbol
  • TACTILE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.77
cell type or tissue
0.73
gene perturbation
0.65
PubMedID
0.61
tissue sample
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.54   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 294   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.54   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 294   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
HSPA1A
Tchem
Novelty:  0.00069195
p_int:  0.999993408
p_ni:  0.000006592
Score:  0.345
Data Source:  BioPlex,STRINGDB
NPTX1
Tbio
Novelty:  0.02872516
p_int:  0.987527411
p_ni:  0.012472588
p_wrong:  1e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
SQSTM1
Tbio
Novelty:  0.00100555
p_int:  0.952239612
p_ni:  0.047760388
Score:  0.187
Data Source:  BioPlex,STRINGDB
TMEM160
Tdark
Novelty:  0.73483266
p_int:  0.790086793
p_ni:  0.209913207
Score:  0.209
Data Source:  BioPlex,STRINGDB
NOMO1
Tbio
Novelty:  0.13625697
p_int:  0.787025262
p_ni:  0.212974738
Score:  0.416
Data Source:  BioPlex,STRINGDB
PVR
Tbio
Novelty:  0.00215811
Score:  0.992
Data Source:  Reactome,STRINGDB
TIGIT
Tbio
Novelty:  0.0064542
Score:  0.765
Data Source:  STRINGDB
NECTIN2
Tbio
Novelty:  0.00910836
Score:  0.752
Data Source:  STRINGDB
CLEC12A
Tbio
Novelty:  0.01478908
Score:  0.686
Data Source:  STRINGDB
COLEC10
Tbio
Novelty:  0.02593638
Score:  0.66
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to TNF antagonist
1
1
0
15.9
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to TNF antagonist
0
15.9
33.1
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD96 molecule
VGNC:1769
460577
Macaque
CD96 molecule
706836
Mouse
MGI:1934368
84544
Rat
RGD:1565249
498079
Dog
CD96 molecule
VGNC:38982
487972
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD96 molecule
Macaque
CD96 molecule
Mouse
Rat
Dog
CD96 molecule
Publication Statistics
PubMed Score 50.54
PubMed score by year
PubTator Score 27.06
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title