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Tbio
CD93
Complement component C1q receptor

Protein Summary
Description
Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion. The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246006
  • ENSP00000246006
  • ENSG00000125810

Symbol
  • C1QR1
  • MXRA4
  • C1QR1
  • C1qRP
  • CDw93
  • ECSM3
  • MXRA4
  • C1qR(P)
  • dJ737E23.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.91
PubMedID
0.84
disease perturbation
0.79
cell line
0.66


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.93   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 472   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.93   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 472   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (198)
RARS
Tchem
Family:  Enzyme
Novelty:  0.00099479
p_int:  0.978893861
p_ni:  0.021106139
Score:  0.185
Data Source:  BioPlex,STRINGDB
KCTD17
Tbio
Novelty:  0.12105733
p_int:  0.972721054
p_ni:  0.024346527
p_wrong:  0.00293242
Data Source:  BioPlex
ASPH
Tbio
Family:  Enzyme
Novelty:  0.00291455
p_int:  0.966995926
p_ni:  0.033004074
Score:  0.159
Data Source:  BioPlex,STRINGDB
RNF114
Tbio
Family:  Enzyme
Novelty:  0.06758257
p_int:  0.948130121
p_ni:  0.051869879
Score:  0.167
Data Source:  BioPlex,STRINGDB
MEMO1
Tbio
Novelty:  0.0506558
p_int:  0.924766217
p_ni:  0.075233783
Score:  0.188
Data Source:  BioPlex,STRINGDB
ACP2
Tbio
Family:  Enzyme
Novelty:  0.00355652
p_int:  0.917746148
p_ni:  0.082253775
p_wrong:  7.7e-8
Data Source:  BioPlex
ORC4
Tbio
Novelty:  0.01763127
p_int:  0.908632688
p_ni:  0.091367312
Score:  0.188
Data Source:  BioPlex,STRINGDB
CNTNAP1
Tbio
Novelty:  0.00618741
p_int:  0.875025036
p_ni:  0.010350539
p_wrong:  0.114624424
Score:  0.324
Data Source:  BioPlex,STRINGDB
CLDND1
Tbio
Novelty:  0.06681793
p_int:  0.843698266
p_ni:  0.002978248
p_wrong:  0.153323486
Score:  0.183
Data Source:  BioPlex,STRINGDB
ECSIT
Tbio
Novelty:  0.04690184
p_int:  0.80792637
p_ni:  0.192073258
p_wrong:  3.72e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thrombomodulin measurement
1
1
1
88.5
blood protein measurement
1
1
1
83.5
1
2
0
2.2
24.4
cognitive function measurement
1
1
1
3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thrombomodulin measurement
1
88.5
blood protein measurement
1
83.5
0
2.2
24.4
cognitive function measurement
1
3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD93 molecule
VGNC:6072
458137
Macaque
CD93 molecule
702252
Mouse
MGI:106664
17064
Dog
CD93 molecule [Source:HGNC Symbol;Acc:HGNC:15855]
Horse
CD93 molecule
VGNC:51518
100059201
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD93 molecule
Macaque
CD93 molecule
Mouse
Dog
CD93 molecule [Source:HGNC Symbol;Acc:HGNC:15855]
Horse
CD93 molecule
Publication Statistics
PubMed Score 88.93
PubMed score by year
PubTator Score 78.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title