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Tbio
CD9
CD9 antigen

Protein Summary
Description
Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed:8478605, PubMed:14575715, PubMed:18541721). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (PubMed:18541721). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (PubMed:8478605, PubMed:7511626). This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes including ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000009180
  • ENSP00000009180
  • ENSG00000010278
  • ENST00000382518
  • ENSP00000371958
  • ENST00000538834
  • ENSP00000496639

Symbol
  • MIC3
  • TSPAN29
  • MIC3
  • MRP-1
  • BTCC-1
  • DRAP-27
  • TSPAN29
  • TSPAN-29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
disease perturbation
0.96
gene perturbation
0.95
PubMedID
0.84
biological term
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1084   (req: < 5)
Gene RIFs: 117   (req: <= 3)
Antibodies: 1674   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1084   (req: >= 5)
Gene RIFs: 117   (req: > 3)
Antibodies: 1674   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (160)
TSPAN1
Tbio
Novelty:  0.01547855
p_int:  0.99959999
p_ni:  0.000029403
p_wrong:  0.000370607
Score:  0.269
Data Source:  BioPlex,STRINGDB
IGSF8
Tbio
Novelty:  0.03016623
p_int:  0.993714698
p_ni:  4.6e-8
p_wrong:  0.006285257
Score:  0.898
Data Source:  BioPlex,STRINGDB
ITGB1
Tclin
Novelty:  0.00055626
Score:  0.978
Data Source:  STRINGDB
IZUMO1
Tbio
Novelty:  0.01839953
Score:  0.966
Data Source:  Reactome,STRINGDB
ITGA6
Tbio
Novelty:  0.00217985
Score:  0.961
Data Source:  STRINGDB
IZUMO4
Tdark
Novelty:  0.76836026
Score:  0.942
Data Source:  STRINGDB
IZUMO3
Tdark
Novelty:  0.90063897
Score:  0.921
Data Source:  STRINGDB
IZUMO2
Tdark
Novelty:  0.04397237
Score:  0.91
Data Source:  STRINGDB
PTGFRN
Tbio
Novelty:  0.02271483
Score:  0.904
Data Source:  STRINGDB
TSG101
Tbio
Novelty:  0.00211746
Score:  0.879
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Acrosome Reaction and Sperm:Oocyte Membrane Binding (R-HSA-1300645)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acrosome Reaction and Sperm:Oocyte Membrane Binding
Reactome
Disease
Reactome
Fertilization
Reactome
Hemostasis
Reactome
Infectious disease
Name
Explore in Pharos
Explore in Source
Acrosome Reaction and Sperm:Oocyte Membrane Binding
Disease
Fertilization
Hemostasis
Infectious disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
6
7
99
platelet count
3
6
5
2.5
96.5
5
2
0
1.2
92.7
platelet crit
2
3
3
90.9
tumor necrosis factor receptor 1 measurement
1
1
1
81.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
7
99
platelet count
5
2.5
96.5
0
1.2
92.7
platelet crit
3
90.9
tumor necrosis factor receptor 1 measurement
1
81.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD9 molecule
VGNC:12887
451775
Macaque
CD9 molecule
712262
Mouse
MGI:88348
12527
Rat
RGD:2318
24936
Dog
CD9 molecule
VGNC:38981
611695
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD9 molecule
Macaque
CD9 molecule
Mouse
Rat
Dog
CD9 molecule
Publication Statistics
PubMed Score 1084.00
PubMed score by year
PubTator Score 497.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title