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Tbio
CD8B
T-cell surface glycoprotein CD8 beta chain

Protein Summary
Description
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). A ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331469
  • ENSP00000331172
  • ENSG00000172116
  • ENST00000349455
  • ENSP00000340592
  • ENST00000390655
  • ENSP00000375070
  • ENST00000393759
  • ENSP00000377356
  • ENST00000393761
  • ENSP00000377358

Symbol
  • CD8B1
  • LY3
  • P37
  • LEU2
  • LYT3
  • CD8B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.82
gene perturbation
0.67
cell type or tissue
0.66
cellular component
0.65
tissue sample
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.67   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 822   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 256.67   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 822   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0