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Tclin
CD86
T-lymphocyte activation antigen CD86

Protein Summary
Description
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B. This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264468
  • ENSP00000264468
  • ENSG00000114013
  • ENST00000330540
  • ENSP00000332049
  • ENST00000393627
  • ENSP00000377248
  • ENST00000469710
  • ENSP00000418988
  • ENST00000493101
  • ENSP00000420230

Symbol
  • CD28LG2
  • B70
  • B7-2
  • B7.2
  • LAB72
  • CD28LG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
biological term
0.91
disease
0.8
PubMedID
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2986.52   (req: < 5)
Gene RIFs: 141   (req: <= 3)
Antibodies: 1775   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2986.52   (req: >= 5)
Gene RIFs: 141   (req: > 3)
Antibodies: 1775   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (524)
CTLA4
Tclin
Novelty:  0.00012781
Score:  0.999
Data Source:  Reactome,STRINGDB
CD28
Tbio
Novelty:  0.00036482
Score:  0.996
Data Source:  Reactome,STRINGDB
IL10
Tbio
Novelty:  0.00004352
Score:  0.992
Data Source:  STRINGDB
CD80
Tclin
Novelty:  0.00031181
Score:  0.976
Data Source:  STRINGDB
CD83
Tbio
Novelty:  0.00138653
Score:  0.96
Data Source:  STRINGDB
CD40
Tchem
Novelty:  0.0002836
Score:  0.958
Data Source:  STRINGDB
CD3E
Tclin
Novelty:  0.0053855
Score:  0.958
Data Source:  STRINGDB
P04229
Tbio
Novelty:  0.00240724
Score:  0.957
Data Source:  STRINGDB
Q29974
Tbio
Novelty:  0.00240724
Score:  0.957
Data Source:  STRINGDB
Q9TQE0
Tbio
Novelty:  0.00240724
Score:  0.957
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (56)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
CD28 co-stimulation
Reactome
CD28 dependent PI3K/Akt signaling
Reactome
CD28 dependent Vav1 pathway
Reactome
CTLA4 inhibitory signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
9
9
95.5
3
3
0
1.2
88.8
blood urea nitrogen measurement
2
2
2
67.5
eosinophil percentage of leukocytes
1
1
1
62.8
eosinophil count
1
1
1
57.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
9
95.5
0
1.2
88.8
blood urea nitrogen measurement
2
67.5
eosinophil percentage of leukocytes
1
62.8
eosinophil count
1
57.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD86 molecule
VGNC:1768
470900
Macaque
CD86 molecule
714390
Mouse
MGI:101773
12524
Rat
RGD:628714
56822
Dog
CD86 molecule
VGNC:38979
403764
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD86 molecule
Macaque
CD86 molecule
Mouse
Rat
Dog
CD86 molecule
Publication Statistics
PubMed Score 2986.52
PubMed score by year
PubTator Score 1319.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title