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Tclin
CD86
T-lymphocyte activation antigen CD86

Protein Summary
Description
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B. This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264468
  • ENSP00000264468
  • ENSG00000114013
  • ENST00000330540
  • ENSP00000332049
  • ENST00000393627
  • ENSP00000377248
  • ENST00000469710
  • ENSP00000418988
  • ENST00000493101
  • ENSP00000420230

Symbol
  • CD28LG2
  • B70
  • B7-2
  • B7.2
  • LAB72
  • CD28LG2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
biological term
0.91
disease
0.8
PubMedID
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3518.9   (req: < 5)
Gene RIFs: 141   (req: <= 3)
Antibodies: 1775   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3518.9   (req: >= 5)
Gene RIFs: 141   (req: > 3)
Antibodies: 1775   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2