Tbio CD83 CD83 antigen

Protein Summary

Description

May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation. The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q01151
• Q5THX9
• hCD83

Gene Name

• CD83

Ensembl ID

• ENST00000379153
• ENSP00000368450
• ENSG00000112149

Symbol

• BL11
• HB15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.98
gene perturbation	0.95
virus perturbation	0.9
transcription factor binding site profile	0.79
disease	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 679.36   (req: < 5)

Gene RIFs: 56   (req: <= 3)

Antibodies: 863   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 679.36   (req: >= 5)

Gene RIFs: 56   (req: > 3)

Antibodies: 863   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (196)

Explore Interacting Targets

1 – 10 of 196

• See Interactions on String-DB

SLC30A1

Tbio

Family:  Transporter

Novelty:  0.00528427

p_int:  0.999918311

p_ni:  0.000081689

Data Source:  BioPlex

NDST1

Tbio

Family:  Enzyme

Novelty:  0.00955868

p_int:  0.999907688

p_ni:  0.000092312

Data Source:  BioPlex

SLC7A2

Tbio

Family:  Transporter

Novelty:  0.02262224

p_int:  0.999654692

p_ni:  0.000345308

Data Source:  BioPlex

UGCG

Tclin

Family:  Enzyme

Novelty:  0.00481791

p_int:  0.999624967

p_ni:  0.000375022

p_wrong:  1.1e-8

Data Source:  BioPlex

ATP7A

Tbio

Family:  Enzyme

Novelty:  0.00064155

p_int:  0.999356708

p_ni:  0.000643292

Data Source:  BioPlex

C1orf112

Tdark

Novelty:  1.42922586

p_int:  0.997926573

p_ni:  0.002073427

Data Source:  BioPlex

RADIL

Tbio

Novelty:  0.08747353

p_int:  0.997491915

p_ni:  0.002439402

p_wrong:  0.000068683

Data Source:  BioPlex

CERS5

Tbio

Family:  TF

Novelty:  0.02984012

p_int:  0.997310188

p_ni:  0.002578672

p_wrong:  0.000111139

Data Source:  BioPlex

BMPR2

Tchem

Family:  Kinase

Novelty:  0.00155912

p_int:  0.995347583

p_ni:  0.00332471

p_wrong:  0.001327707

Data Source:  BioPlex

USP8

Tchem

Family:  Enzyme

Novelty:  0.0105645

p_int:  0.994232288

p_ni:  0.005767532

p_wrong:  1.8e-7

Score:  0.2

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (2)

WikiPathways (2)

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5

1 – 2 of 2

Data Source	Name	Explore in Pharos	Explore in Source
WikiPathways	Macrophage markers	32 targets	WP4146_r105642
WikiPathways	T-Cell antigen Receptor (TCR) Signaling Pathway	1763 targets	WP69_r103503

Name	Explore in Pharos	Explore in Source
Macrophage markers	32 targets	WP4146_r105642
T-Cell antigen Receptor (TCR) Signaling Pathway	1763 targets	WP69_r103503

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Components (3)

Processes (8)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
integral component of plasma membrane	Traceable Author Statement (TAS)	ProtInc
plasma membrane	Traceable Author Statement (TAS)	ProtInc
external side of plasma membrane	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
caffeine metabolite measurement	EFO_0007872	1	1	0	5.5	1.8
self reported educational attainment	EFO_0004784	1	1	1		1.4
rheumatoid arthritis	EFO_0000685	1	1	0	1.1	1.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
caffeine metabolite measurement	EFO_0007872	0	5.5	1.8
self reported educational attainment	EFO_0004784	1		1.4
rheumatoid arthritis	EFO_0000685	0	1.1	1.1

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Membrane
Polymorphism
Reference proteome
Signal

GWAS Trait Find Similar Targets

No Header	No Header
caffeine metabolite measurement
rheumatoid arthritis
self reported educational attainment

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
immune system phenotype
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	CD83 molecule	VGNC:11041	462446
Macaque	CD83 molecule		701825
Mouse	CD83 antigen	MGI:1328316	12522
Rat	CD83 molecule	RGD:1309677	361226
Dog	CD83 molecule	VGNC:38977	610141

Species	Name	OMA	EggNOG	Inparanoid
Chimp	CD83 molecule
Macaque	CD83 molecule
Mouse	CD83 antigen
Rat	CD83 molecule
Dog	CD83 molecule

Publication Statistics

PubMed Score 679.36

PubMed score by year

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PubTator Score 521.27

PubTator score by year

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Related Publications

Text Mined References (73)

GeneRif Annotations (56)

Items per page:

10

0 of 0

PMID	Year	Title