Protein Summary
May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation. The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- ENST00000379153
- ENSP00000368450
- ENSG00000112149
- BL11
- HB15
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.98 | ||
gene perturbation | 0.95 | ||
virus perturbation | 0.9 | ||
transcription factor binding site profile | 0.79 | ||
disease | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 679.36 (req: < 5)
Gene RIFs: 56 (req: <= 3)
Antibodies: 863 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 679.36 (req: >= 5)
Gene RIFs: 56 (req: > 3)
Antibodies: 863 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (196)
SLC30A1
Family: Transporter
Novelty: 0.00528427
p_int: 0.999918311
p_ni: 0.000081689
Data Source: BioPlex
NDST1
Family: Enzyme
Novelty: 0.00955868
p_int: 0.999907688
p_ni: 0.000092312
Data Source: BioPlex
SLC7A2
Family: Transporter
Novelty: 0.02262224
p_int: 0.999654692
p_ni: 0.000345308
Data Source: BioPlex
UGCG
Family: Enzyme
Novelty: 0.00481791
p_int: 0.999624967
p_ni: 0.000375022
p_wrong: 1.1e-8
Data Source: BioPlex
ATP7A
Family: Enzyme
Novelty: 0.00064155
p_int: 0.999356708
p_ni: 0.000643292
Data Source: BioPlex
RADIL
Novelty: 0.08747353
p_int: 0.997491915
p_ni: 0.002439402
p_wrong: 0.000068683
Data Source: BioPlex
CERS5
Family: TF
Novelty: 0.02984012
p_int: 0.997310188
p_ni: 0.002578672
p_wrong: 0.000111139
Data Source: BioPlex
BMPR2
Family: Kinase
Novelty: 0.00155912
p_int: 0.995347583
p_ni: 0.00332471
p_wrong: 0.001327707
Data Source: BioPlex
USP8
Family: Enzyme
Novelty: 0.0105645
p_int: 0.994232288
p_ni: 0.005767532
p_wrong: 1.8e-7
Score: 0.2
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (2)
WikiPathways (2)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
WikiPathways | Macrophage markers | ||||
WikiPathways | T-Cell antigen Receptor (TCR) Signaling Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Macrophage markers | ||||
T-Cell antigen Receptor (TCR) Signaling Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Components (3)
Processes (8)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
caffeine metabolite measurement | 1 | 1 | 0 | 5.5 | 1.8 | ||||
self reported educational attainment | 1 | 1 | 1 | 1.4 | |||||
1 | 1 | 0 | 1.1 | 1.1 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
caffeine metabolite measurement | 0 | 5.5 | 1.8 | ||||
self reported educational attainment | 1 | 1.4 | |||||
0 | 1.1 | 1.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | CD83 molecule | VGNC:11041 | 462446 | |||||
Macaque | CD83 molecule | 701825 | ||||||
Mouse | MGI:1328316 | 12522 | ||||||
Rat | RGD:1309677 | 361226 | ||||||
Dog | CD83 molecule | VGNC:38977 | 610141 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | CD83 molecule | |||||
Macaque | CD83 molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD83 molecule | |||||
Publication Statistics
PubMed Score 679.36
PubMed score by year
PubTator Score 521.27
PubTator score by year
Related Publications
Text Mined References (73)
GeneRif Annotations (56)
Items per page:
0 of 0
PMID | Year | Title |
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