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Tbio
CD83
CD83 antigen

Protein Summary
Description
May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation. The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379153
  • ENSP00000368450
  • ENSG00000112149

Symbol
  • BL11
  • HB15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
gene perturbation
0.95
virus perturbation
0.9
transcription factor binding site profile
0.79
disease
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 679.36   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 863   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 679.36   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 863   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (196)
SLC30A1
Tbio
Family:  Transporter
Novelty:  0.00528427
p_int:  0.999918311
p_ni:  0.000081689
Data Source:  BioPlex
NDST1
Tbio
Family:  Enzyme
Novelty:  0.00955868
p_int:  0.999907688
p_ni:  0.000092312
Data Source:  BioPlex
SLC7A2
Tbio
Family:  Transporter
Novelty:  0.02262224
p_int:  0.999654692
p_ni:  0.000345308
Data Source:  BioPlex
UGCG
Tclin
Family:  Enzyme
Novelty:  0.00481791
p_int:  0.999624967
p_ni:  0.000375022
p_wrong:  1.1e-8
Data Source:  BioPlex
ATP7A
Tbio
Family:  Enzyme
Novelty:  0.00064155
p_int:  0.999356708
p_ni:  0.000643292
Data Source:  BioPlex
C1orf112
Tdark
Novelty:  1.42922586
p_int:  0.997926573
p_ni:  0.002073427
Data Source:  BioPlex
RADIL
Tbio
Novelty:  0.08747353
p_int:  0.997491915
p_ni:  0.002439402
p_wrong:  0.000068683
Data Source:  BioPlex
CERS5
Tbio
Family:  TF
Novelty:  0.02984012
p_int:  0.997310188
p_ni:  0.002578672
p_wrong:  0.000111139
Data Source:  BioPlex
BMPR2
Tchem
Family:  Kinase
Novelty:  0.00155912
p_int:  0.995347583
p_ni:  0.00332471
p_wrong:  0.001327707
Data Source:  BioPlex
USP8
Tchem
Family:  Enzyme
Novelty:  0.0105645
p_int:  0.994232288
p_ni:  0.005767532
p_wrong:  1.8e-7
Score:  0.2
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
caffeine metabolite measurement
1
1
0
5.5
1.8
self reported educational attainment
1
1
1
1.4
1
1
0
1.1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
caffeine metabolite measurement
0
5.5
1.8
self reported educational attainment
1
1.4
0
1.1
1.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD83 molecule
VGNC:11041
462446
Macaque
CD83 molecule
701825
Mouse
MGI:1328316
12522
Rat
RGD:1309677
361226
Dog
CD83 molecule
VGNC:38977
610141
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD83 molecule
Macaque
CD83 molecule
Mouse
Rat
Dog
CD83 molecule
Publication Statistics
PubMed Score 679.36
PubMed score by year
PubTator Score 521.27
PubTator score by year
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Related Publications
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PMID
Year
Title