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Tbio
CD82
CD82 antigen

Protein Summary
Description
Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227155
  • ENSP00000227155
  • ENSG00000085117
  • ENST00000342935
  • ENSP00000339686

Symbol
  • KAI1
  • SAR2
  • ST6
  • TSPAN27
  • R2
  • 4F9
  • C33
  • IA4
  • ST6
  • GR15
  • KAI1
  • SAR2
  • TSPAN27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.84
transcription factor binding site profile
0.8
gene perturbation
0.74
transcription factor perturbation
0.74
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 910.83   (req: < 5)
Gene RIFs: 173   (req: <= 3)
Antibodies: 543   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 910.83   (req: >= 5)
Gene RIFs: 173   (req: > 3)
Antibodies: 543   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0