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Tclin
CD80
T-lymphocyte activation antigen CD80

Protein Summary
Description
Involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. (Microbial infection) Acts as a receptor for adenovirus subgroup B. The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264246
  • ENSP00000264246
  • ENSG00000121594
  • ENST00000383669
  • ENSP00000373165
  • ENST00000478182
  • ENSP00000418364

Symbol
  • CD28LG
  • CD28LG1
  • LAB7
  • B7
  • BB1
  • B7-1
  • B7.1
  • LAB7
  • CD28LG
  • CD28LG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
biological term
0.89
chemical
0.88
gene perturbation
0.78
virus perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3244.67   (req: < 5)
Gene RIFs: 122   (req: <= 3)
Antibodies: 1889   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3244.67   (req: >= 5)
Gene RIFs: 122   (req: > 3)
Antibodies: 1889   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2