You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
CD79B
B-cell antigen receptor complex-associated protein beta chain

Protein Summary
Description
Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000006750
  • ENSP00000006750
  • ENSG00000007312
  • ENST00000349817
  • ENSP00000245862
  • ENST00000392795
  • ENSP00000376544

Symbol
  • B29
  • IGB
  • B29
  • IGB
  • AGM6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
PubMedID
0.72
gene perturbation
0.7
kinase perturbation
0.66
cellular component
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 404   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 879   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 404   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 879   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (264)
TBRG4
Tbio
Novelty:  0.03556613
p_int:  0.999931994
p_ni:  0.000068006
Data Source:  BioPlex
NF1
Tbio
Novelty:  0.00019092
p_int:  0.999902981
p_ni:  0.000097019
Score:  0.167
Data Source:  BioPlex,STRINGDB
SLC12A6
Tbio
Family:  Transporter
Novelty:  0.0132619
p_int:  0.999888941
p_ni:  0.000110315
p_wrong:  7.44e-7
Data Source:  BioPlex
TRPM4
Tchem
Family:  IC
Novelty:  0.00423106
p_int:  0.999868217
p_ni:  0.000131782
p_wrong:  1e-9
Data Source:  BioPlex
TSC2
Tbio
Novelty:  0.00067416
p_int:  0.99975998
p_ni:  0.000239989
p_wrong:  3.1e-8
Data Source:  BioPlex
CYBC1
Tdark
Novelty:  0.72567331
p_int:  0.999687343
p_ni:  0.000268796
p_wrong:  0.000043861
Data Source:  BioPlex
ENTPD4
Tbio
Family:  Enzyme
Novelty:  0.11023026
p_int:  0.999687343
p_ni:  0.000268796
p_wrong:  0.000043861
Data Source:  BioPlex
TMTC4
Tdark
Novelty:  0.53734704
p_int:  0.999679249
p_ni:  0.00032075
Data Source:  BioPlex
MANEA
Tbio
Family:  Enzyme
Novelty:  0.03693244
p_int:  0.999659198
p_ni:  0.000340802
Data Source:  BioPlex
TMUB2
Tdark
Novelty:  1.76302035
p_int:  0.999485088
p_ni:  0.000447
p_wrong:  0.000067912
Data Source:  BioPlex
Pathways (11)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
CD22 mediated BCR regulation
Reactome
Immune System
Reactome
Signaling by the B Cell Receptor (BCR)
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
CD22 mediated BCR regulation
Immune System
Signaling by the B Cell Receptor (BCR)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
7
8
10
97.7
IGF-1 measurement
1
2
2
95.2
BMI-adjusted hip circumference
2
8
9
93.3
appendicular lean mass
2
2
4
91.1
hematocrit
2
2
2
88.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
10
97.7
IGF-1 measurement
2
95.2
BMI-adjusted hip circumference
9
93.3
appendicular lean mass
4
91.1
hematocrit
2
88.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD79b molecule
VGNC:9180
454773
Mouse
MGI:96431
15985
Rat
RGD:620012
171055
Dog
CD79b molecule
VGNC:38974
609449
Cow
CD79b molecule
VGNC:27047
509801
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD79b molecule
Mouse
Rat
Dog
CD79b molecule
Cow
CD79b molecule
Publication Statistics
PubMed Score 404.00
PubMed score by year
PubTator Score 201.40
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title