Tbio CD70 CD70 antigen

Protein Summary

Description

Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P32970
• B4DPR8
• Q53XX4
• Q96J57

Gene Name

• CD70

Ensembl ID

• ENST00000245903
• ENSP00000245903
• ENSG00000125726
• ENST00000423145
• ENSP00000395294

Symbol

• CD27L
• CD27LG
• TNFSF7
• CD27L
• LPFS3
• CD27-L
• CD27LG
• TNFSF7
• TNLG8A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.84
cell type or tissue	0.81
biological term	0.66
disease	0.63
tissue	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.25   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 759   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 277.25   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 759   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (150)

Explore Interacting Targets

1 – 10 of 150

• See Interactions on String-DB

KDM8

Tbio

Family:  Epigenetic

Novelty:  0.03368031

p_int:  0.999997964

p_ni:  0.000001363

p_wrong:  6.73e-7

Data Source:  BioPlex

TNFRSF13B

Tbio

Novelty:  0.00338954

p_int:  0.999996663

p_ni:  0.00000151

p_wrong:  0.000001827

Score:  0.459

Data Source:  BioPlex,STRINGDB

CD27

Tbio

Novelty:  0.00090508

p_int:  0.999982532

p_ni:  0.00001164

p_wrong:  0.000005827

Score:  0.994

Data Source:  BioPlex,Reactome,STRINGDB

SEC14L1

Tbio

Novelty:  0.09562071

p_int:  0.999965226

p_ni:  0.000028311

p_wrong:  0.000006463

Data Source:  BioPlex

TNFRSF17

Tclin

Novelty:  0.00222663

p_int:  0.999956133

p_ni:  0.000012136

p_wrong:  0.000031731

Score:  0.353

Data Source:  BioPlex,STRINGDB

TAMM41

Tbio

Family:  Enzyme

Novelty:  0.06004824

p_int:  0.999942466

p_ni:  0.000057533

p_wrong:  2e-9

Data Source:  BioPlex

FANCG

Tbio

Novelty:  0.00908902

p_int:  0.999868

p_ni:  0.000127717

p_wrong:  0.000004283

Data Source:  BioPlex

NR2C2

Tchem

Family:  NR

Novelty:  0.00392355

p_int:  0.999825023

p_ni:  0.000001318

p_wrong:  0.000173659

Score:  0.177

Data Source:  BioPlex,STRINGDB

PDXDC1

Tbio

Family:  Enzyme

Novelty:  0.16529476

p_int:  0.999818703

p_ni:  0.000181297

Data Source:  BioPlex

UTP20

Tbio

Novelty:  0.09170451

p_int:  0.999723741

p_ni:  0.000276259

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (4)

KEGG (1)

Cytokine Signaling in Immune system (R-HSA-1280215)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	TNFR2 non-canonical NF-kB pathway	101 targets	R-HSA-5668541
Reactome	TNFs bind their physiological receptors	28 targets	R-HSA-5669034

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Immune System	2246 targets	R-HSA-168256
TNFR2 non-canonical NF-kB pathway	101 targets	R-HSA-5668541
TNFs bind their physiological receptors	28 targets	R-HSA-5669034

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (4)

Components (3)

Processes (6)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
protease binding	Inferred from Physical Interaction (IPI)	BHF-UCL
signaling receptor binding	Traceable Author Statement (TAS)	ProtInc
cytokine activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
tumor necrosis factor receptor binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (13)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 13

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
tumor necrosis factor ligand superfamily member 14 measurement	EFO_0010613	1	3	3		96.7
monocyte count	EFO_0005091	3	2	3		88.3
multiple sclerosis	EFO_0003885	3	1	0	1.2	80.7
monocyte percentage of leukocytes	EFO_0007989	2	2	2		80.4
blood protein measurement	EFO_0007937	1	1	1		80.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 13

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
tumor necrosis factor ligand superfamily member 14 measurement	EFO_0010613	3		96.7
monocyte count	EFO_0005091	3		88.3
multiple sclerosis	EFO_0003885	0	1.2	80.7
monocyte percentage of leukocytes	EFO_0007989	2		80.4
blood protein measurement	EFO_0007937	1		80.4

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Cytokine
Disulfide bond
Glycoprotein
Membrane
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix

GWAS Trait Find Similar Targets

No Header	No Header
asthma
blood protein measurement
complement C3 measurement
complement C4 measurement
granulocyte percentage of myeloid white cells
leukocyte count
lymphocyte count
monocyte count
monocyte percentage of leukocytes
multiple sclerosis

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
immune system phenotype

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	CD70 molecule		701080
Mouse	CD70 antigen	MGI:1195273	21948
Rat	Cd70 molecule	RGD:1588573	301132
Dog	CD70 molecule	VGNC:38970	485018
Horse	CD70 molecule	VGNC:16278	100065854

Species	Name	OMA	EggNOG	Inparanoid
Macaque	CD70 molecule
Mouse	CD70 antigen
Rat	Cd70 molecule
Dog	CD70 molecule
Horse	CD70 molecule

Publication Statistics

PubMed Score 277.25

PubMed score by year

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PubTator Score 156.36

PubTator score by year

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Related Publications

Text Mined References (86)

GeneRif Annotations (55)

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PMID	Year	Title