Protein Summary
Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
- ENST00000245903
- ENSP00000245903
- ENSG00000125726
- ENST00000423145
- ENSP00000395294
- CD27L
- CD27LG
- TNFSF7
- CD27L
- LPFS3
- CD27-L
- CD27LG
- TNFSF7
- TNLG8A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.84 | ||
cell type or tissue | 0.81 | ||
biological term | 0.66 | ||
disease | 0.63 | ||
tissue | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 277.25 (req: < 5)
Gene RIFs: 55 (req: <= 3)
Antibodies: 759 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 277.25 (req: >= 5)
Gene RIFs: 55 (req: > 3)
Antibodies: 759 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (150)
KDM8
Family: Epigenetic
Novelty: 0.03368031
p_int: 0.999997964
p_ni: 0.000001363
p_wrong: 6.73e-7
Data Source: BioPlex
TNFRSF13B
Novelty: 0.00338954
p_int: 0.999996663
p_ni: 0.00000151
p_wrong: 0.000001827
Score: 0.459
Data Source: BioPlex,STRINGDB
CD27
Novelty: 0.00090508
p_int: 0.999982532
p_ni: 0.00001164
p_wrong: 0.000005827
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
SEC14L1
Novelty: 0.09562071
p_int: 0.999965226
p_ni: 0.000028311
p_wrong: 0.000006463
Data Source: BioPlex
TNFRSF17
Novelty: 0.00222663
p_int: 0.999956133
p_ni: 0.000012136
p_wrong: 0.000031731
Score: 0.353
Data Source: BioPlex,STRINGDB
TAMM41
Family: Enzyme
Novelty: 0.06004824
p_int: 0.999942466
p_ni: 0.000057533
p_wrong: 2e-9
Data Source: BioPlex
FANCG
Novelty: 0.00908902
p_int: 0.999868
p_ni: 0.000127717
p_wrong: 0.000004283
Data Source: BioPlex
NR2C2
Family: NR
Novelty: 0.00392355
p_int: 0.999825023
p_ni: 0.000001318
p_wrong: 0.000173659
Score: 0.177
Data Source: BioPlex,STRINGDB
PDXDC1
Family: Enzyme
Novelty: 0.16529476
p_int: 0.999818703
p_ni: 0.000181297
Data Source: BioPlex
Nearest Tclin Targets
Pathways (5)
Reactome (4)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | TNFR2 non-canonical NF-kB pathway | ||||
Reactome | TNFs bind their physiological receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
TNFR2 non-canonical NF-kB pathway | ||||
TNFs bind their physiological receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (4)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
tumor necrosis factor ligand superfamily member 14 measurement | 1 | 3 | 3 | 96.7 | |||||
monocyte count | 3 | 2 | 3 | 88.3 | |||||
3 | 1 | 0 | 1.2 | 80.7 | |||||
monocyte percentage of leukocytes | 2 | 2 | 2 | 80.4 | |||||
blood protein measurement | 1 | 1 | 1 | 80.4 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
tumor necrosis factor ligand superfamily member 14 measurement | 3 | 96.7 | |||||
monocyte count | 3 | 88.3 | |||||
0 | 1.2 | 80.7 | |||||
monocyte percentage of leukocytes | 2 | 80.4 | |||||
blood protein measurement | 1 | 80.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | CD70 molecule | 701080 | ||||||
Mouse | MGI:1195273 | 21948 | ||||||
Rat | RGD:1588573 | 301132 | ||||||
Dog | CD70 molecule | VGNC:38970 | 485018 | |||||
Horse | CD70 molecule | VGNC:16278 | 100065854 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | CD70 molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD70 molecule | |||||
Horse | CD70 molecule | |||||
Publication Statistics
PubMed Score 277.25
PubMed score by year
PubTator Score 156.36
PubTator score by year
Related Publications
Text Mined References (86)
GeneRif Annotations (55)
Items per page:
0 of 0
PMID | Year | Title |
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