Protein Summary
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger r ...more
- ENST00000250092
- ENSP00000250092
- ENSG00000129226
- ENST00000380498
- ENSP00000369867
- GP110
- LAMP4
- SCARD1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.88 | ||
virus perturbation | 0.88 | ||
gene perturbation | 0.85 | ||
disease perturbation | 0.83 | ||
cellular component | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5229.66 (req: < 5)
Gene RIFs: 63 (req: <= 3)
Antibodies: 2041 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5229.66 (req: >= 5)
Gene RIFs: 63 (req: > 3)
Antibodies: 2041 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (344)
GRN
Novelty: 0.00096395
p_int: 0.996312756
p_ni: 0.003687205
p_wrong: 4e-8
Score: 0.649
Data Source: BioPlex,STRINGDB
KIF14
Novelty: 0.02313641
p_int: 0.995149674
p_ni: 0.004850326
Score: 0.193
Data Source: BioPlex,STRINGDB
LGALS1
Novelty: 0.00106509
p_int: 0.988327051
p_ni: 0.011672602
p_wrong: 3.47e-7
Score: 0.237
Data Source: BioPlex,STRINGDB
MTX3
Novelty: 0.06082176
p_int: 0.984945184
p_ni: 0.015054815
Score: 0.201
Data Source: BioPlex,STRINGDB
RARS
Family: Enzyme
Novelty: 0.00099479
p_int: 0.930907561
p_ni: 0.069092439
Score: 0.209
Data Source: BioPlex,STRINGDB
TNPO2
Novelty: 0.10454262
p_int: 0.910076957
p_ni: 0.089923041
p_wrong: 2e-9
Data Source: BioPlex
SAAL1
Novelty: 0.33089811
p_int: 0.880795377
p_ni: 0.119204514
p_wrong: 1.1e-7
Score: 0.175
Data Source: BioPlex,STRINGDB
TTI1
Novelty: 0.05516406
p_int: 0.79394311
p_ni: 0.206020101
p_wrong: 0.000036789
Score: 0.188
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (32)
Reactome (3)
KEGG (1)
WikiPathways (28)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Components (5)
Processes (1)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations (null)
GWAS Traits (64)
Items per page:
1 – 5 of 64
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 10 | 27 | 37 | 100 | |||||
sex hormone-binding globulin measurement | 8 | 8 | 21 | 99.7 | |||||
serum non-albumin protein measurement | 3 | 9 | 11 | 99.2 | |||||
blood protein measurement | 2 | 7 | 7 | 97.6 | |||||
hormone measurement | 2 | 3 | 1 | 57 | 94.8 | ||||
Items per page:
1 – 5 of 64
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
testosterone measurement | 37 | 100 | |||||
sex hormone-binding globulin measurement | 21 | 99.7 | |||||
serum non-albumin protein measurement | 11 | 99.2 | |||||
blood protein measurement | 7 | 97.6 | |||||
hormone measurement | 1 | 57 | 94.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | CD68 molecule | VGNC:9178 | 100615283 | |||||
Macaque | CD68 molecule | 715923 | ||||||
Mouse | MGI:88342 | 12514 | ||||||
Rat | RGD:1305970 | 287435 | ||||||
Dog | CD68 molecule | VGNC:49704 | 111095877 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | CD68 molecule | |||||
Macaque | CD68 molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD68 molecule | |||||
Publication Statistics
PubMed Score 5229.66
PubMed score by year
PubTator Score 2661.88
PubTator score by year
Related Publications
Text Mined References (76)
GeneRif Annotations (63)
Items per page:
0 of 0
PMID | Year | Title |
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