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Tbio
CD68
Macrosialin

Protein Summary
Description
Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250092
  • ENSP00000250092
  • ENSG00000129226
  • ENST00000380498
  • ENSP00000369867

Symbol
  • GP110
  • LAMP4
  • SCARD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.88
virus perturbation
0.88
gene perturbation
0.85
disease perturbation
0.83
cellular component
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5229.66   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 2041   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5229.66   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 2041   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (344)
GRN
Tbio
Novelty:  0.00096395
p_int:  0.996312756
p_ni:  0.003687205
p_wrong:  4e-8
Score:  0.649
Data Source:  BioPlex,STRINGDB
KIF14
Tbio
Novelty:  0.02313641
p_int:  0.995149674
p_ni:  0.004850326
Score:  0.193
Data Source:  BioPlex,STRINGDB
LGALS1
Tchem
Novelty:  0.00106509
p_int:  0.988327051
p_ni:  0.011672602
p_wrong:  3.47e-7
Score:  0.237
Data Source:  BioPlex,STRINGDB
MTX3
Tdark
Novelty:  0.06082176
p_int:  0.984945184
p_ni:  0.015054815
Score:  0.201
Data Source:  BioPlex,STRINGDB
RARS
Tchem
Family:  Enzyme
Novelty:  0.00099479
p_int:  0.930907561
p_ni:  0.069092439
Score:  0.209
Data Source:  BioPlex,STRINGDB
TNPO2
Tbio
Novelty:  0.10454262
p_int:  0.910076957
p_ni:  0.089923041
p_wrong:  2e-9
Data Source:  BioPlex
SAAL1
Tdark
Novelty:  0.33089811
p_int:  0.880795377
p_ni:  0.119204514
p_wrong:  1.1e-7
Score:  0.175
Data Source:  BioPlex,STRINGDB
BZW2
Tbio
Novelty:  0.17006204
p_int:  0.857023052
p_ni:  0.142976948
Data Source:  BioPlex
TTI1
Tbio
Novelty:  0.05516406
p_int:  0.79394311
p_ni:  0.206020101
p_wrong:  0.000036789
Score:  0.188
Data Source:  BioPlex,STRINGDB
CEACAM8
Tbio
Novelty:  0.00370138
Score:  0.942
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (32)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (64)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
10
27
37
100
sex hormone-binding globulin measurement
8
8
21
99.7
serum non-albumin protein measurement
3
9
11
99.2
blood protein measurement
2
7
7
97.6
hormone measurement
2
3
1
57
94.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
37
100
sex hormone-binding globulin measurement
21
99.7
serum non-albumin protein measurement
11
99.2
blood protein measurement
7
97.6
hormone measurement
1
57
94.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD68 molecule
VGNC:9178
100615283
Macaque
CD68 molecule
715923
Mouse
MGI:88342
12514
Rat
RGD:1305970
287435
Dog
CD68 molecule
VGNC:49704
111095877
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD68 molecule
Macaque
CD68 molecule
Mouse
Rat
Dog
CD68 molecule
Publication Statistics
PubMed Score 5229.66
PubMed score by year
PubTator Score 2661.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title