Tbio CD68 Macrosialin

Protein Summary

Description

Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P34810
• B4DVT4
• Q53HR6
• Q53XI3
• Q96BI7

Gene Name

• CD68

Ensembl ID

• ENST00000250092
• ENSP00000250092
• ENSG00000129226
• ENST00000380498
• ENSP00000369867

Symbol

• GP110
• LAMP4
• SCARD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.88
virus perturbation	0.88
gene perturbation	0.85
disease perturbation	0.83
cellular component	0.78

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Macrosialin

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Macrosialin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5229.66   (req: < 5)

Gene RIFs: 63   (req: <= 3)

Antibodies: 2041   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5229.66   (req: >= 5)

Gene RIFs: 63   (req: > 3)

Antibodies: 2041   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (344)

Explore Interacting Targets

1 – 10 of 344

• See Interactions on String-DB

GRN

Tbio

Novelty:  0.00096395

p_int:  0.996312756

p_ni:  0.003687205

p_wrong:  4e-8

Score:  0.649

Data Source:  BioPlex,STRINGDB

KIF14

Tbio

Novelty:  0.02313641

p_int:  0.995149674

p_ni:  0.004850326

Score:  0.193

Data Source:  BioPlex,STRINGDB

LGALS1

Tchem

Novelty:  0.00106509

p_int:  0.988327051

p_ni:  0.011672602

p_wrong:  3.47e-7

Score:  0.237

Data Source:  BioPlex,STRINGDB

MTX3

Tdark

Novelty:  0.06082176

p_int:  0.984945184

p_ni:  0.015054815

Score:  0.201

Data Source:  BioPlex,STRINGDB

RARS

Tchem

Family:  Enzyme

Novelty:  0.00099479

p_int:  0.930907561

p_ni:  0.069092439

Score:  0.209

Data Source:  BioPlex,STRINGDB

TNPO2

Tbio

Novelty:  0.10454262

p_int:  0.910076957

p_ni:  0.089923041

p_wrong:  2e-9

Data Source:  BioPlex

SAAL1

Tdark

Novelty:  0.33089811

p_int:  0.880795377

p_ni:  0.119204514

p_wrong:  1.1e-7

Score:  0.175

Data Source:  BioPlex,STRINGDB

BZW2

Tbio

Novelty:  0.17006204

p_int:  0.857023052

p_ni:  0.142976948

Data Source:  BioPlex

TTI1

Tbio

Novelty:  0.05516406

p_int:  0.79394311

p_ni:  0.206020101

p_wrong:  0.000036789

Score:  0.188

Data Source:  BioPlex,STRINGDB

CEACAM8

Tbio

Novelty:  0.00370138

Score:  0.942

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (32)

Reactome (3)

KEGG (1)

WikiPathways (28)

Immune System (R-HSA-168256)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249
Reactome	Neutrophil degranulation	543 targets	R-HSA-6798695

Name	Explore in Pharos	Explore in Source
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249
Neutrophil degranulation	543 targets	R-HSA-6798695

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Components (5)

Processes (1)

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GO Term	Evidence	Assigned by
azurophil granule membrane	Traceable Author Statement (TAS)	Reactome
integral component of membrane	Traceable Author Statement (TAS)	ProtInc
membrane	Traceable Author Statement (TAS)	ProtInc
plasma membrane	Traceable Author Statement (TAS)	Reactome
endosome membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Disease Associations (null)

No disease associations found

GWAS Traits (64)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 64

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	10	27	37		100
sex hormone-binding globulin measurement	EFO_0004696	8	8	21		99.7
serum non-albumin protein measurement	EFO_0004568	3	9	11		99.2
blood protein measurement	EFO_0007937	2	7	7		97.6
hormone measurement	EFO_0004730	2	3	1	57	94.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 64

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
testosterone measurement	EFO_0004908	37		100
sex hormone-binding globulin measurement	EFO_0004696	21		99.7
serum non-albumin protein measurement	EFO_0004568	11		99.2
blood protein measurement	EFO_0007937	7		97.6
hormone measurement	EFO_0004730	1	57	94.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
Endosome
Glycoprotein
Lysosome
Membrane
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
age at onset
albumin:globulin ratio measurement
alcohol consumption measurement
apolipoprotein A 1 measurement
apolipoprotein B measurement
appendicular lean mass
atrial fibrillation
basal cell carcinoma
birth weight
bitter alcoholic beverage consumption measurement

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
immune system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	CD68 molecule	VGNC:9178	100615283
Macaque	CD68 molecule		715923
Mouse	CD68 antigen	MGI:88342	12514
Rat	Cd68 molecule	RGD:1305970	287435
Dog	CD68 molecule	VGNC:49704	111095877

Species	Name	OMA	EggNOG	Inparanoid
Chimp	CD68 molecule
Macaque	CD68 molecule
Mouse	CD68 antigen
Rat	Cd68 molecule
Dog	CD68 molecule

Publication Statistics

PubMed Score 5229.66

PubMed score by year

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PubTator Score 2661.88

PubTator score by year

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Related Publications

Text Mined References (76)

GeneRif Annotations (63)

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PMID	Year	Title