Protein Summary
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. The protein encoded by this gene is a member of th ...more
- ENST00000257857
- ENSP00000257857
- ENSG00000135404
- ENST00000420846
- ENSP00000393502
- ENST00000546939
- ENSP00000447356
- ENST00000549117
- ENSP00000447730
- ENST00000550776
- ENSP00000448091
- ENST00000552692
- ENSP00000449337
- ENST00000552754
- ENSP00000446807
- MLA1
- TSPAN30
- MLA1
- ME491
- LAMP-3
- OMA81H
- TSPAN30
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 0.95 | ||
PubMedID | 0.86 | ||
disease | 0.85 | ||
transcription factor binding site profile | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1431.12 (req: < 5)
Gene RIFs: 69 (req: <= 3)
Antibodies: 1768 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1431.12 (req: >= 5)
Gene RIFs: 69 (req: > 3)
Antibodies: 1768 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 11
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (11)
Protein-Protein Interactions (216)
RETREG3
Novelty: 0.99215801
p_int: 0.999358995
p_ni: 0.000583267
p_wrong: 0.000057738
Score: 0.185
Data Source: BioPlex,STRINGDB
LGALS9
Novelty: 0.00381766
p_int: 0.985084815
p_ni: 0.014165752
p_wrong: 0.000749432
Score: 0.422
Data Source: BioPlex,STRINGDB
LGALS8
Novelty: 0.00623836
p_int: 0.968415256
p_ni: 0.030446582
p_wrong: 0.001138162
Score: 0.182
Data Source: BioPlex,STRINGDB
TSPAN2
Novelty: 0.03842973
p_int: 0.957540493
p_ni: 0.041369199
p_wrong: 0.001090308
Score: 0.816
Data Source: BioPlex,STRINGDB
LGALS3
Novelty: 0.00032754
p_int: 0.943680806
p_ni: 0.055991896
p_wrong: 0.000327298
Score: 0.508
Data Source: BioPlex,STRINGDB
TMEM47
Novelty: 0.1571161
p_int: 0.936343015
p_ni: 0.063656975
p_wrong: 1.1e-8
Data Source: BioPlex
TMEM208
Novelty: 0.63059333
p_int: 0.935744792
p_ni: 0.064139369
p_wrong: 0.000115839
Data Source: BioPlex
TSPAN31
Novelty: 0.13580467
p_int: 0.911198547
p_ni: 0.088780038
p_wrong: 0.000021414
Score: 0.494
Data Source: BioPlex,STRINGDB
SLC7A14
Family: Transporter
Novelty: 0.1613451
p_int: 0.882588032
p_ni: 0.117328615
p_wrong: 0.000083353
Data Source: BioPlex
FAM241A
Novelty: 1.04041354
p_int: 0.877948542
p_ni: 0.12198723
p_wrong: 0.000064228
Data Source: BioPlex
Nearest Tclin Targets
Pathways (19)
Reactome (7)
KEGG (2)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Hemostasis | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Reactome | Platelet activation, signaling and aggregation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Hemostasis | ||||
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Platelet activation, signaling and aggregation | ||||
Viral Interactions (0)
Gene Ontology Terms (29)
Components (15)
Processes (14)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
refractive error measurement | 3 | 3 | 3 | 13.8 | 96.4 | ||||
Myopia | 3 | 2 | 0 | 1.3 | 93 | ||||
age at onset | 1 | 1 | 0 | 13.8 | 83.1 | ||||
Abnormality of refraction | 1 | 1 | 1 | 53.3 | |||||
atrophic macular degeneration | 1 | 1 | 0 | 1.2 | 30.2 | ||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
refractive error measurement | 3 | 13.8 | 96.4 | ||||
Myopia | 0 | 1.3 | 93 | ||||
age at onset | 0 | 13.8 | 83.1 | ||||
Abnormality of refraction | 1 | 53.3 | |||||
atrophic macular degeneration | 0 | 1.2 | 30.2 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | CD63 molecule | VGNC:12886 | 451969 | |||||
Macaque | CD63 molecule | 709828 | ||||||
Mouse | MGI:99529 | 12512 | ||||||
Rat | RGD:62080 | 29186 | ||||||
Dog | CD63 molecule | VGNC:38967 | 474391 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | CD63 molecule | |||||
Macaque | CD63 molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD63 molecule | |||||
Publication Statistics
PubMed Score 1431.12
PubMed score by year
PubTator Score 707.36
PubTator score by year
Related Publications
Text Mined References (127)
GeneRif Annotations (69)
Items per page:
0 of 0
PMID | Year | Title |
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