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Tchem
CD63
CD63 antigen

Protein Summary
Description
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. The protein encoded by this gene is a member of th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257857
  • ENSP00000257857
  • ENSG00000135404
  • ENST00000420846
  • ENSP00000393502
  • ENST00000546939
  • ENSP00000447356
  • ENST00000549117
  • ENSP00000447730
  • ENST00000550776
  • ENSP00000448091
  • ENST00000552692
  • ENSP00000449337
  • ENST00000552754
  • ENSP00000446807

Symbol
  • MLA1
  • TSPAN30
  • MLA1
  • ME491
  • LAMP-3
  • OMA81H
  • TSPAN30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.95
PubMedID
0.86
disease
0.85
transcription factor binding site profile
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1861.74   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 1768   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1861.74   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 1768   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0