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Tbio
CD5
T-cell surface glycoprotein CD5

Protein Summary
Description
May act as a receptor in regulating T-cell proliferation. This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes, T lymphocytes and a subset of B lymphocytes. The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347785
  • ENSP00000342681
  • ENSG00000110448

Symbol
  • LEU1
  • T1
  • LEU1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.88
cell type or tissue
0.85
gene perturbation
0.82
hub protein
0.82
cell line
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3034.05   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 3371   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3034.05   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 3371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (213)
CD2
Tclin
Novelty:  0.00037283
Score:  0.978
Data Source:  STRINGDB
CD4
Tclin
Novelty:  0.00001217
Score:  0.953
Data Source:  STRINGDB
CD19
Tclin
Novelty:  0.0001816
Score:  0.928
Data Source:  STRINGDB
CD7
Tbio
Novelty:  0.00107937
Score:  0.924
Data Source:  STRINGDB
CD79A
Tbio
Novelty:  0.00118942
Score:  0.908
Data Source:  STRINGDB
MME
Tclin
Family:  Enzyme
Novelty:  0.00019144
Score:  0.898
Data Source:  STRINGDB
SPN
Tbio
Novelty:  0.00121061
Score:  0.877
Data Source:  STRINGDB
CR2
Tbio
Novelty:  0.00086638
Score:  0.874
Data Source:  STRINGDB
ZAP70
Tchem
Family:  Kinase
Novelty:  0.0011564
Score:  0.87
Data Source:  STRINGDB
LCK
Tclin
Family:  Kinase
Novelty:  0.00058377
Score:  0.869
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
0
1.1
90
CD6 measurement
1
1
1
67.3
2
1
0
1.1
61.4
eosinophil count
3
3
3
60.9
1
1
0
1.1
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
90
CD6 measurement
1
67.3
0
1.1
61.4
eosinophil count
3
60.9
0
1.1
47.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD5 molecule
VGNC:3157
737721
Macaque
CD5 molecule
695249
Mouse
MGI:88340
12507
Rat
RGD:2309
54236
Rat
RGD:6494271
100911215
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD5 molecule
Macaque
CD5 molecule
Mouse
Rat
Rat
Publication Statistics
PubMed Score 3034.05
PubMed score by year
PubTator Score 2066.76
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title