Protein Summary
Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation. This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
- ENST00000368045
- ENSP00000357024
- ENSG00000117091
- ENST00000368046
- ENSP00000357025
- BCM1
- BLAST1
- BCM1
- BLAST
- hCD48
- mCD48
- BLAST1
- SLAMF2
- MEM-102
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.85 | ||
protein domain | 0.73 | ||
kinase perturbation | 0.71 | ||
cellular component | 0.67 | ||
tissue | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 380.37 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 956 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 380.37 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 956 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (165)
PRAP1
Novelty: 0.08146257
p_int: 0.999995901
p_ni: 0.000003918
p_wrong: 1.81e-7
Score: 0.68
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (7)
Reactome (2)
KEGG (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Hemostasis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell surface interactions at the vascular wall | ||||
Hemostasis | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (6)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 3 | 0 | 1.1 | 78.3 | |||||
eosinophil count | 2 | 2 | 2 | 74.4 | |||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 57.3 | |||||
serum IgM measurement | 1 | 1 | 1 | 30.2 | |||||
memory performance | 1 | 1 | 1 | 15.8 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 78.3 | |||||
eosinophil count | 2 | 74.4 | |||||
eosinophil percentage of leukocytes | 1 | 57.3 | |||||
serum IgM measurement | 1 | 30.2 | |||||
memory performance | 1 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | CD48 molecule | VGNC:5013 | 457437 | |||||
Macaque | CD48 molecule | 719762 | ||||||
Mouse | MGI:88339 | 12506 | ||||||
Rat | RGD:620620 | 245962 | ||||||
Dog | CD48 molecule | VGNC:38961 | 488642 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | CD48 molecule | |||||
Macaque | CD48 molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD48 molecule | |||||
Publication Statistics
PubMed Score 380.37
PubMed score by year
PubTator Score 230.52
PubTator score by year
Related Publications
Text Mined References (57)
GeneRif Annotations (28)
Items per page:
0 of 0
PMID | Year | Title |
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