Protein Summary
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, ...more
- ENST00000263398
- ENSP00000263398
- ENSG00000026508
- ENST00000278386
- ENSP00000278386
- ENST00000352818
- ENSP00000309732
- ENST00000415148
- ENSP00000389830
- ENST00000428726
- ENSP00000398632
- ENST00000433892
- ENSP00000392331
- ENST00000434472
- ENSP00000404447
- LHR
- MDU2
- MDU3
- MIC4
- IN
- LHR
- MC56
- MDU2
- MDU3
- MIC4
- Pgp1
- CDW44
- CSPG8
- HCELL
- HUTCH-I
- ECMR-III
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 1 | ||
biological process | 0.99 | ||
gene perturbation | 0.94 | ||
microRNA | 0.94 | ||
PubMedID | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8647.08 (req: < 5)
Gene RIFs: 982 (req: <= 3)
Antibodies: 4804 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8647.08 (req: >= 5)
Gene RIFs: 982 (req: > 3)
Antibodies: 4804 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (765)
VCAN
Novelty: 0.00110986
p_int: 0.999999564
p_ni: 4.35e-7
p_wrong: 1e-9
Score: 0.844
Data Source: BioPlex,STRINGDB
GMEB2
Family: TF
Novelty: 0.1945427
p_int: 0.99999877
p_ni: 1.25e-7
p_wrong: 0.000001105
Score: 0.439
Data Source: BioPlex,STRINGDB
FGF2
Novelty: 0.00007856
p_int: 0.999998694
p_ni: 6.1e-8
p_wrong: 0.000001246
Score: 0.89
Data Source: BioPlex,STRINGDB
GMEB1
Family: TF
Novelty: 0.10522678
p_int: 0.999998072
p_ni: 0.000001921
p_wrong: 7e-9
Score: 0.439
Data Source: BioPlex,STRINGDB
DHRS2
Family: Enzyme
Novelty: 0.002032
p_int: 0.999997811
p_ni: 0.000002189
Score: 0.188
Data Source: BioPlex,STRINGDB
METTL8
Family: Enzyme
Novelty: 0.24190691
p_int: 0.99999713
p_ni: 0.000002857
p_wrong: 1.3e-8
Data Source: BioPlex
IRAK3
Family: Kinase
Novelty: 0.01001206
p_int: 0.999984325
p_ni: 0.000015562
p_wrong: 1.12e-7
Score: 0.263
Data Source: BioPlex,STRINGDB
TCAF2
Family: Enzyme
Novelty: 0.37070492
p_int: 0.999976722
p_ni: 0.000023278
Data Source: BioPlex
SLC39A9
Family: Transporter
Novelty: 0.06143625
p_int: 0.99997619
p_ni: 0.00002381
Data Source: BioPlex
AMPD2
Family: Enzyme
Novelty: 0.01510718
p_int: 0.999955489
p_ni: 0.000044508
p_wrong: 3e-9
Data Source: BioPlex
Nearest Tclin Targets (4)
Upstream (1)
Downstream (3)
1 – 1 of 1
Pathways (95)
Reactome (18)
KEGG (6)
PathwayCommons (12)
WikiPathways (59)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Degradation of the extracellular matrix | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Glycosaminoglycan metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell surface interactions at the vascular wall | ||||
Cytokine Signaling in Immune system | ||||
Degradation of the extracellular matrix | ||||
Extracellular matrix organization | ||||
Glycosaminoglycan metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (41)
Functions (3)
Components (14)
Processes (24)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 3 | 6 | 85.4 | |||||
2 | 2 | 0 | 1.2 | 81.4 | |||||
4 | 3 | 0 | 1.2 | 76.1 | |||||
Thyroid preparation use measurement | 1 | 1 | 1 | 70.9 | |||||
autoimmune thyroid disease | 1 | 1 | 0 | 1.1 | 68.6 | ||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 6 | 85.4 | |||||
0 | 1.2 | 81.4 | |||||
0 | 1.2 | 76.1 | |||||
Thyroid preparation use measurement | 1 | 70.9 | |||||
autoimmune thyroid disease | 0 | 1.1 | 68.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | CD44 molecule | VGNC:3158 | 451122 | |||||
Macaque | CD44 molecule (Indian blood group) | 717204 | ||||||
Mouse | MGI:88338 | 12505 | ||||||
Rat | RGD:2307 | 25406 | ||||||
Dog | CD44 molecule | VGNC:51860 | 403939 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | CD44 molecule | |||||
Macaque | CD44 molecule (Indian blood group) | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD44 molecule | |||||
Publication Statistics
PubMed Score 8647.08
PubMed score by year
PubTator Score 4570.60
PubTator score by year
Related Publications
Text Mined References (1089)
GeneRif Annotations (982)
Items per page:
0 of 0
PMID | Year | Title |
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