Tbio CD44 CD44 antigen

Protein Summary

Description

Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P16070
• A5YRN9
• B6EAT9
• D3DR12
• D3DR13
• O95370
• P22511
• Q04858
• Q13419
• Q13957
• Q13958
• Q13959
• Q13960
• Q13961
• Q13967
• Q13968
• Q13980
• Q15861
• Q16064
• Q16065
• Q16066
• Q16208
• Q16522
• Q86T72
• Q86Z27
• Q8N694
• Q92493
• Q96J24
• Q9H5A5
• Q9UC28
• Q9UC29
• Q9UC30
• Q9UCB0
• Q9UJ36

Gene Name

• CD44

Ensembl ID

• ENST00000263398
• ENSP00000263398
• ENSG00000026508
• ENST00000278386
• ENSP00000278386
• ENST00000352818
• ENSP00000309732
• ENST00000415148
• ENSP00000389830
• ENST00000428726
• ENSP00000398632
• ENST00000433892
• ENSP00000392331
• ENST00000434472
• ENSP00000404447

Symbol

• LHR
• MDU2
• MDU3
• MIC4
• IN
• LHR
• MC56
• MDU2
• MDU3
• MIC4
• Pgp1
• CDW44
• CSPG8
• HCELL
• HUTCH-I
• ECMR-III

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
biological process	0.99
gene perturbation	0.94
microRNA	0.94
PubMedID	0.86

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8647.08   (req: < 5)

Gene RIFs: 982   (req: <= 3)

Antibodies: 4804   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8647.08   (req: >= 5)

Gene RIFs: 982   (req: > 3)

Antibodies: 4804   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (765)

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1 – 10 of 765

• See Interactions on String-DB

VCAN

Tbio

Novelty:  0.00110986

p_int:  0.999999564

p_ni:  4.35e-7

p_wrong:  1e-9

Score:  0.844

Data Source:  BioPlex,STRINGDB

GMEB2

Tdark

Family:  TF

Novelty:  0.1945427

p_int:  0.99999877

p_ni:  1.25e-7

p_wrong:  0.000001105

Score:  0.439

Data Source:  BioPlex,STRINGDB

FGF2

Tchem

Novelty:  0.00007856

p_int:  0.999998694

p_ni:  6.1e-8

p_wrong:  0.000001246

Score:  0.89

Data Source:  BioPlex,STRINGDB

GMEB1

Tbio

Family:  TF

Novelty:  0.10522678

p_int:  0.999998072

p_ni:  0.000001921

p_wrong:  7e-9

Score:  0.439

Data Source:  BioPlex,STRINGDB

DHRS2

Tbio

Family:  Enzyme

Novelty:  0.002032

p_int:  0.999997811

p_ni:  0.000002189

Score:  0.188

Data Source:  BioPlex,STRINGDB

METTL8

Tdark

Family:  Enzyme

Novelty:  0.24190691

p_int:  0.99999713

p_ni:  0.000002857

p_wrong:  1.3e-8

Data Source:  BioPlex

IRAK3

Tchem

Family:  Kinase

Novelty:  0.01001206

p_int:  0.999984325

p_ni:  0.000015562

p_wrong:  1.12e-7

Score:  0.263

Data Source:  BioPlex,STRINGDB

TCAF2

Tbio

Family:  Enzyme

Novelty:  0.37070492

p_int:  0.999976722

p_ni:  0.000023278

Data Source:  BioPlex

SLC39A9

Tbio

Family:  Transporter

Novelty:  0.06143625

p_int:  0.99997619

p_ni:  0.00002381

Data Source:  BioPlex

AMPD2

Tchem

Family:  Enzyme

Novelty:  0.01510718

p_int:  0.999955489

p_ni:  0.000044508

p_wrong:  3e-9

Data Source:  BioPlex

Nearest Tclin Targets (4)

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Upstream (1)

Downstream (3)

1 – 1 of 1

ERBB2

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  2

1: Proteoglycans in cancer

2: MicroRNAs in cancer

Pathways (95)

Reactome (18)

KEGG (6)

PathwayCommons (12)

WikiPathways (59)

Cell surface interactions at the vascular wall (R-HSA-202733)

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5

1 – 5 of 18

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Degradation of the extracellular matrix	111 targets	R-HSA-1474228
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244
Reactome	Glycosaminoglycan metabolism	122 targets	R-HSA-1630316

Name	Explore in Pharos	Explore in Source
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Degradation of the extracellular matrix	111 targets	R-HSA-1474228
Extracellular matrix organization	297 targets	R-HSA-1474244
Glycosaminoglycan metabolism	122 targets	R-HSA-1630316

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (41)

Functions (3)

Components (14)

Processes (24)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
hyaluronic acid binding	Inferred from Direct Assay (IDA)	UniProtKB
transmembrane signaling receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
collagen binding	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3	3	6		85.4
Vitiligo	EFO_0004208	2	2	0	1.2	81.4
systemic lupus erythematosus	EFO_0002690	4	3	0	1.2	76.1
Thyroid preparation use measurement	EFO_0009933	1	1	1		70.9
autoimmune thyroid disease	EFO_0006812	1	1	0	1.1	68.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	6		85.4
Vitiligo	EFO_0004208	0	1.2	81.4
systemic lupus erythematosus	EFO_0002690	0	1.2	76.1
Thyroid preparation use measurement	EFO_0009933	1		70.9
autoimmune thyroid disease	EFO_0006812	0	1.1	68.6

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Blood group antigen
Cell adhesion
Cell membrane
Cell projection
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein

GWAS Trait Find Similar Targets

No Header	No Header
autoimmune thyroid disease
bone density
FEV/FEC ratio
heel bone mineral density
sex hormone-binding globulin measurement
systemic lupus erythematosus
Thyroid preparation use measurement
uterine fibroid
Vitiligo

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
digestive/alimentary phenotype
endocrine/exocrine gland phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
limbs/digits/tail phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	CD44 molecule	VGNC:3158	451122
Macaque	CD44 molecule (Indian blood group)		717204
Mouse	CD44 antigen	MGI:88338	12505
Rat	CD44 molecule (Indian blood group)	RGD:2307	25406
Dog	CD44 molecule	VGNC:51860	403939

Species	Name	OMA	EggNOG	Inparanoid
Chimp	CD44 molecule
Macaque	CD44 molecule (Indian blood group)
Mouse	CD44 antigen
Rat	CD44 molecule (Indian blood group)
Dog	CD44 molecule

Publication Statistics

PubMed Score 8647.08

PubMed score by year

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PubTator Score 4570.60

PubTator score by year

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Related Publications

Text Mined References (1089)

GeneRif Annotations (982)

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10

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PMID	Year	Title