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Tbio
CD3EAP
DNA-directed RNA polymerase I subunit RPA34

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Isoform 1 is involved in UBTF-activated transcription, presumably at a step following PIC formation. Isoform 2 has been described as a component of preformed T-cell receptor (TCR) complex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309424
  • ENSP00000310966
  • ENSG00000117877
  • ENST00000589804
  • ENSP00000465099

Symbol
  • ASE1
  • CAST
  • PAF49
  • ASE1
  • CAST
  • ASE-1
  • PAF49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.83
transcription factor binding site profile
0.83
histone modification site profile
0.82
cellular component
0.75
cell type or tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.48   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.48   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
POLR1C
Tbio
Family:  Enzyme
Novelty:  0.04485332
p_int:  0.999999632
p_ni:  3.53e-7
p_wrong:  1.5e-8
Score:  0.987
Data Source:  BioPlex,STRINGDB
RRN3
Tbio
Family:  Enzyme
Novelty:  0.01643149
p_int:  0.999861617
p_ni:  0.000090713
p_wrong:  0.00004767
Score:  0.966
Data Source:  BioPlex,STRINGDB
POLR2E
Tbio
Family:  Enzyme
Novelty:  0.01817288
p_int:  0.998488091
p_ni:  0.001509452
p_wrong:  0.000002458
Score:  0.982
Data Source:  BioPlex,STRINGDB
GPN3
Tbio
Family:  Enzyme
Novelty:  0.13817794
p_int:  0.998468867
p_ni:  0.001531121
p_wrong:  1.2e-8
Score:  0.525
Data Source:  BioPlex,STRINGDB
SCRN1
Tbio
Family:  Enzyme
Novelty:  0.08315012
p_int:  0.991121693
p_ni:  0.008051208
p_wrong:  0.000827099
Score:  0.187
Data Source:  BioPlex,STRINGDB
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.983469487
p_ni:  0.016530506
p_wrong:  7e-9
Data Source:  BioPlex
SNX21
Tdark
Novelty:  0.32916633
p_int:  0.955867789
p_ni:  0.042917107
p_wrong:  0.001215103
Score:  0.181
Data Source:  BioPlex,STRINGDB
POLR1E
Tbio
Family:  Enzyme
Novelty:  0.09991103
Score:  0.998
Data Source:  STRINGDB
TAF1A
Tbio
Family:  Enzyme
Novelty:  0.10734794
Score:  0.982
Data Source:  STRINGDB
ERCC2
Tchem
Family:  Enzyme
Novelty:  0.00240155
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
B-WICH complex positively regulates rRNA expression (R-HSA-5250924)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Negative epigenetic regulation of rRNA expression
Reactome
NoRC negatively regulates rRNA expression
Name
Explore in Pharos
Explore in Source
B-WICH complex positively regulates rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Negative epigenetic regulation of rRNA expression
NoRC negatively regulates rRNA expression
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
4
4
7
98.4
heel bone mineral density
3
4
6
91.1
apolipoprotein B measurement
1
5
5
88.7
low density lipoprotein cholesterol measurement
1
3
3
76.7
response to statin
1
1
1
66
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
7
98.4
heel bone mineral density
6
91.1
apolipoprotein B measurement
5
88.7
low density lipoprotein cholesterol measurement
3
76.7
response to statin
1
66
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD3e molecule associated protein
VGNC:6616
745146
Macaque
CD3e molecule associated protein
714440
Mouse
MGI:1917583
70333
Rat
RGD:1591707
680493
Dog
CD3e molecule associated protein
VGNC:38956
612284
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD3e molecule associated protein
Macaque
CD3e molecule associated protein
Mouse
Rat
Dog
CD3e molecule associated protein
Publication Statistics
PubMed Score 19.48
PubMed score by year
PubTator Score 18.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title