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Tclin
CD3D
T-cell surface glycoprotein CD3 delta chain

Protein Summary
Description
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300692
  • ENSP00000300692
  • ENSG00000167286
  • ENST00000392884
  • ENSP00000376622

Symbol
  • T3D
  • T3D
  • IMD19
  • CD3-DELTA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.72
biological process
0.71
tissue sample
0.7
small molecule perturbation
0.64
tissue
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.93   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 801   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 177.93   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 801   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (336)
CD3E
Tclin
Novelty:  0.0053855
Score:  0.999
Data Source:  Reactome,STRINGDB
CD247
Tbio
Novelty:  0.00217194
Score:  0.995
Data Source:  Reactome,STRINGDB
CD3G
Tclin
Novelty:  0.00466154
Score:  0.989
Data Source:  Reactome,STRINGDB
CD8B
Tbio
Novelty:  0.00382722
Score:  0.987
Data Source:  Reactome,STRINGDB
ZAP70
Tchem
Family:  Kinase
Novelty:  0.0011564
Score:  0.986
Data Source:  Reactome,STRINGDB
LCK
Tclin
Family:  Kinase
Novelty:  0.00058377
Score:  0.985
Data Source:  Reactome,STRINGDB
ITK
Tclin
Family:  Kinase
Novelty:  0.00054195
Score:  0.976
Data Source:  STRINGDB
CD8A
Tbio
Novelty:  0.00002519
Score:  0.973
Data Source:  Reactome,STRINGDB
TRAT1
Tbio
Novelty:  0.0015709
Score:  0.964
Data Source:  STRINGDB
CD28
Tbio
Novelty:  0.00036482
Score:  0.956
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (205)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Costimulation by the CD28 family
Reactome
Downstream TCR signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Costimulation by the CD28 family
Downstream TCR signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
64.2
hemoglobin measurement
2
1
2
58.4
sleep duration
1
1
0
1.2
52.7
1
1
0
1.1
40.7
monocyte percentage of leukocytes
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
64.2
hemoglobin measurement
2
58.4
sleep duration
0
1.2
52.7
0
1.1
40.7
monocyte percentage of leukocytes
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD3d molecule
VGNC:6481
451584
Macaque
CD3d molecule
699582
Mouse
MGI:88331
12500
Rat
RGD:2304
25710
Dog
CD3d molecule
VGNC:38954
479419
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD3d molecule
Macaque
CD3d molecule
Mouse
Rat
Dog
CD3d molecule
Publication Statistics
PubMed Score 177.93
PubMed score by year
PubTator Score 93.90
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title