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Tclin
CD38
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Protein Summary
Description
Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226279
  • ENSP00000226279
  • ENSG00000004468
  • ENST00000502843
  • ENSP00000427277

Symbol
  • ADPRC1
  • ADPRC 1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
biological process
0.98
biological term
0.98
transcription factor perturbation
0.8
disease
0.71


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3466.6   (req: < 5)
Gene RIFs: 193   (req: <= 3)
Antibodies: 2188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3466.6   (req: >= 5)
Gene RIFs: 193   (req: > 3)
Antibodies: 2188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 85
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2