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Tclin
CD38
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Protein Summary
Description
Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226279
  • ENSP00000226279
  • ENSG00000004468
  • ENST00000502843
  • ENSP00000427277

Symbol
  • ADPRC1
  • ADPRC 1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
biological process
0.98
biological term
0.98
transcription factor perturbation
0.8
disease
0.71


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2927.74   (req: < 5)
Gene RIFs: 193   (req: <= 3)
Antibodies: 2188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2927.74   (req: >= 5)
Gene RIFs: 193   (req: > 3)
Antibodies: 2188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 85
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (271)
NAMPT
Tchem
Family:  Enzyme
Novelty:  0.00093316
Score:  0.941
Data Source:  STRINGDB
NMNAT1
Tbio
Family:  Enzyme
Novelty:  0.01110899
Score:  0.933
Data Source:  STRINGDB
NADK
Tbio
Family:  Kinase
Novelty:  0.02812925
Score:  0.932
Data Source:  STRINGDB
NMNAT3
Tbio
Family:  Enzyme
Novelty:  0.03261313
Score:  0.926
Data Source:  STRINGDB
NNMT
Tchem
Family:  Enzyme
Novelty:  0.00602892
Score:  0.923
Data Source:  STRINGDB
NMNAT2
Tbio
Family:  Enzyme
Novelty:  0.01709189
Score:  0.922
Data Source:  STRINGDB
ENPP3
Tchem
Family:  Enzyme
Novelty:  0.00414129
Score:  0.918
Data Source:  STRINGDB
ENPP1
Tchem
Family:  Enzyme
Novelty:  0.00256132
Score:  0.918
Data Source:  STRINGDB
PNP
Tclin
Family:  Enzyme
Novelty:  0.0019084
Score:  0.914
Data Source:  STRINGDB
BST1
Tbio
Family:  Enzyme
Novelty:  0.01329061
Score:  0.913
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinate metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (38)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
4
1
1.1
88.1
vitamin D measurement
3
2
3
50.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
88.1
vitamin D measurement
3
50.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD38 molecule
VGNC:6415
745433
Macaque
CD38 molecule
714399
Mouse
MGI:107474
12494
Rat
RGD:2303
25668
Dog
CD38 molecule
VGNC:38953
403756
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD38 molecule
Macaque
CD38 molecule
Mouse
Rat
Dog
CD38 molecule
Publication Statistics
PubMed Score 2927.74
PubMed score by year
PubTator Score 1813.61
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title