Tclin CD38 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1

Protein Summary

Description

Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Uniprot Accession IDs

• P28907
• O00121
• O00122
• Q96HY4

Gene Name

• CD38

Ensembl ID

• ENST00000226279
• ENSP00000226279
• ENSG00000004468
• ENST00000502843
• ENSP00000427277

Symbol

• ADPRC1
• ADPRC 1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.99
biological process	0.98
biological term	0.98
transcription factor perturbation	0.8
disease	0.71

Protein Classes

PANTHER Classes

Protein / Lyase / Cyclase / Adp-ribosyl Cyclase/cyclic Adp-ribose Hydrolase 1

Protein / Hydrolase / Glycosidase / Adp-ribosyl Cyclase/cyclic Adp-ribose Hydrolase 1

DTO Classes

Protein / Enzyme / Lyase / Cyclase / Adp-ribosyl Cyclase/cyclic Adp-ribose Hydrolase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3466.6   (req: < 5)

Gene RIFs: 261   (req: <= 3)

Antibodies: 2188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3466.6   (req: >= 5)

Gene RIFs: 261   (req: > 3)

Antibodies: 2188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 85

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2