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Tbio
CD37
Leukocyte antigen CD37

Protein Summary
Description
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323906
  • ENSP00000325708
  • ENSG00000104894
  • ENST00000426897
  • ENSP00000413151
  • ENST00000598095
  • ENSP00000470394

Symbol
  • TSPAN26
  • GP52-40
  • TSPAN26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.93
gene perturbation
0.65
tissue sample
0.63
protein domain
0.58
transcription factor
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.46   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 488   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.46   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 488   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
CD19
Tclin
Novelty:  0.0001816
Score:  0.689
Data Source:  STRINGDB
CD22
Tclin
Novelty:  0.0009372
Score:  0.673
Data Source:  STRINGDB
CLEC7A
Tbio
Novelty:  0.00162014
Score:  0.646
Data Source:  STRINGDB
PBDC1
Tdark
Novelty:  0.79983498
Score:  0.642
Data Source:  STRINGDB
MYSM1
Tbio
Family:  TF
Novelty:  0.03983046
Score:  0.635
Data Source:  STRINGDB
TSPAN32
Tbio
Novelty:  0.08323845
Score:  0.634
Data Source:  STRINGDB
TM4SF1
Tbio
Novelty:  0.02410436
Score:  0.628
Data Source:  STRINGDB
CD52
Tclin
Novelty:  0.00142013
Score:  0.625
Data Source:  STRINGDB
UPK1A
Tbio
Novelty:  0.01748122
Score:  0.622
Data Source:  STRINGDB
IRF8
Tbio
Family:  TF
Novelty:  0.00330143
Score:  0.593
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
83.5
serum albumin measurement
1
1
1
57.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
83.5
serum albumin measurement
1
57.3
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD37 molecule
VGNC:10963
456200
Macaque
CD37 molecule
718718
Mouse
MGI:88330
12493
Rat
RGD:62035
29185
Dog
CD37 molecule
VGNC:38952
484382
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD37 molecule
Macaque
CD37 molecule
Mouse
Rat
Dog
CD37 molecule
Publication Statistics
PubMed Score 131.46
PubMed score by year
PubTator Score 71.26
PubTator score by year
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Related Publications
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PMID
Year
Title