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Tbio
CD36
Platelet glycoprotein 4

Protein Summary
Description
Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine (Probable). Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption (By similarity) (PubMed:18353783, P ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309881
  • ENSP00000308165
  • ENSG00000135218
  • ENST00000394788
  • ENSP00000378268
  • ENST00000432207
  • ENSP00000411411
  • ENST00000433696
  • ENSP00000401863
  • ENST00000435819
  • ENSP00000399421
  • ENST00000447544
  • ENSP00000415743
  • ENST00000538969
  • ENSP00000439543
  • ENST00000544133
  • ENSP00000441956

Symbol
  • GP3B
  • GP4
  • FAT
  • GP4
  • GP3B
  • GPIV
  • CHDS7
  • PASIV
  • SCARB3
  • BDPLT10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
metabolite
1
gene perturbation
0.97
disease
0.79
molecular function
0.79


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2214.29   (req: < 5)
Gene RIFs: 337   (req: <= 3)
Antibodies: 1595   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2214.29   (req: >= 5)
Gene RIFs: 337   (req: > 3)
Antibodies: 1595   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 84
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0