Protein Summary
Receptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389). Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213). Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells (PubMed:10727470). Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation (PubMed:10727470, PubMed:11418631). Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) (PubMed:11418631). CD320 augments the proliferation of PC precursors generated by IL-10 (PubMed:11418631). This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are a ...more
- ENST00000301458
- ENSP00000301458
- ENSG00000167775
- ENST00000537716
- ENSP00000437697
- 8D6A
- 8D6
- 8D6A
- TCBLR
- TCN2R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.85 | ||
pathway | 0.78 | ||
disease perturbation | 0.74 | ||
transcription factor binding site profile | 0.73 | ||
cellular component | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 55.82 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 146 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 55.82 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 146 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (54)
TMX1
Novelty: 0.03444237
p_int: 0.999794811
p_ni: 0.000204223
p_wrong: 9.65e-7
Data Source: BioPlex
TM4SF18
Novelty: 0.16102348
p_int: 0.996338439
p_ni: 0.003661364
p_wrong: 1.98e-7
Score: 0.165
Data Source: BioPlex,STRINGDB
TSPAN3
Novelty: 0.06362133
p_int: 0.985911913
p_ni: 0.010357795
p_wrong: 0.003730292
Data Source: BioPlex
ARRDC3
Novelty: 0.04840692
p_int: 0.985539055
p_ni: 0.010598982
p_wrong: 0.003861964
Data Source: BioPlex
TPCN2
Family: IC
Novelty: 0.01351129
p_int: 0.972039885
p_ni: 0.025309876
p_wrong: 0.002650239
Data Source: BioPlex
CLEC4A
Novelty: 0.01821643
p_int: 0.952653471
p_ni: 0.043151715
p_wrong: 0.004194813
Data Source: BioPlex
IFNGR1
Novelty: 0.00417244
p_int: 0.947081282
p_ni: 0.052867445
p_wrong: 0.000051273
Data Source: BioPlex
IL2RG
Novelty: 0.00108272
p_int: 0.928431385
p_ni: 0.071564676
p_wrong: 0.000003939
Score: 0.189
Data Source: BioPlex,STRINGDB
LTBR
Novelty: 0.003823
p_int: 0.924591898
p_ni: 0.075406758
p_wrong: 0.000001344
Data Source: BioPlex
LITAF
Family: TF
Novelty: 0.0097203
p_int: 0.923388706
p_ni: 0.076609956
p_wrong: 0.000001338
Data Source: BioPlex
Nearest Tclin Targets
Pathways (10)
Reactome (9)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Reactome | Defective CD320 causes methylmalonic aciduria | ||||
Reactome | Defects in cobalamin (B12) metabolism | ||||
Reactome | Defects in vitamin and cofactor metabolism | ||||
Reactome | Disease | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Defective CD320 causes methylmalonic aciduria | ||||
Defects in cobalamin (B12) metabolism | ||||
Defects in vitamin and cofactor metabolism | ||||
Disease | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (4)
Components (5)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (23)
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 13 | 8 | 20 | 4 | 99.5 | ||||
triglyceride measurement | 9 | 3 | 12 | 98 | |||||
apolipoprotein A 1 measurement | 2 | 3 | 4 | 97.1 | |||||
red blood cell distribution width | 2 | 3 | 4 | 93.3 | |||||
very long-chain saturated fatty acid measurement | 3 | 2 | 0 | 10 | 91.9 | ||||
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
high density lipoprotein cholesterol measurement | 20 | 4 | 99.5 | ||||
triglyceride measurement | 12 | 98 | |||||
apolipoprotein A 1 measurement | 4 | 97.1 | |||||
red blood cell distribution width | 4 | 93.3 | |||||
very long-chain saturated fatty acid measurement | 0 | 10 | 91.9 | ||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | CD320 molecule | VGNC:2367 | 456436 | |||||
Macaque | CD320 molecule | 711130 | ||||||
Mouse | MGI:1860083 | 54219 | ||||||
Rat | RGD:1305860 | 362851 | ||||||
Dog | CD320 molecule | VGNC:38949 | 100855567 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | CD320 molecule | |||||
Macaque | CD320 molecule | |||||
Mouse | ||||||
Rat | ||||||
Dog | CD320 molecule | |||||
Publication Statistics
PubMed Score 55.82
PubMed score by year
PubTator Score 26.37
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (18)
Items per page:
0 of 0
PMID | Year | Title |
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