Tbio CD320 CD320 antigen

Protein Summary

Description

Receptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389). Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213). Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells (PubMed:10727470). Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation (PubMed:10727470, PubMed:11418631). Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) (PubMed:11418631). CD320 augments the proliferation of PC precursors generated by IL-10 (PubMed:11418631). This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• Q9NPF0
• B2RDS5
• D6W668
• F5H6D3
• Q53HF7

Gene Name

• CD320

Ensembl ID

• ENST00000301458
• ENSP00000301458
• ENSG00000167775
• ENST00000537716
• ENSP00000437697

Symbol

• 8D6A
• 8D6
• 8D6A
• TCBLR
• TCN2R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.85
pathway	0.78
disease perturbation	0.74
transcription factor binding site profile	0.73
cellular component	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.82   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 146   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.82   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (54)

Explore Interacting Targets

1 – 10 of 54

• See Interactions on String-DB

TMX1

Tbio

Novelty:  0.03444237

p_int:  0.999794811

p_ni:  0.000204223

p_wrong:  9.65e-7

Data Source:  BioPlex

TM4SF18

Tbio

Novelty:  0.16102348

p_int:  0.996338439

p_ni:  0.003661364

p_wrong:  1.98e-7

Score:  0.165

Data Source:  BioPlex,STRINGDB

TSPAN3

Tbio

Novelty:  0.06362133

p_int:  0.985911913

p_ni:  0.010357795

p_wrong:  0.003730292

Data Source:  BioPlex

ARRDC3

Tbio

Novelty:  0.04840692

p_int:  0.985539055

p_ni:  0.010598982

p_wrong:  0.003861964

Data Source:  BioPlex

TPCN2

Tchem

Family:  IC

Novelty:  0.01351129

p_int:  0.972039885

p_ni:  0.025309876

p_wrong:  0.002650239

Data Source:  BioPlex

CLEC4A

Tbio

Novelty:  0.01821643

p_int:  0.952653471

p_ni:  0.043151715

p_wrong:  0.004194813

Data Source:  BioPlex

IFNGR1

Tbio

Novelty:  0.00417244

p_int:  0.947081282

p_ni:  0.052867445

p_wrong:  0.000051273

Data Source:  BioPlex

IL2RG

Tclin

Novelty:  0.00108272

p_int:  0.928431385

p_ni:  0.071564676

p_wrong:  0.000003939

Score:  0.189

Data Source:  BioPlex,STRINGDB

LTBR

Tbio

Novelty:  0.003823

p_int:  0.924591898

p_ni:  0.075406758

p_wrong:  0.000001344

Data Source:  BioPlex

LITAF

Tbio

Family:  TF

Novelty:  0.0097203

p_int:  0.923388706

p_ni:  0.076609956

p_wrong:  0.000001338

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (10)

Reactome (9)

WikiPathways (1)

Cobalamin (Cbl, vitamin B12) transport and metabolism (R-HSA-196741)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cobalamin (Cbl, vitamin B12) transport and metabolism	19 targets	R-HSA-196741
Reactome	Defective CD320 causes methylmalonic aciduria	2 targets	R-HSA-3359485
Reactome	Defects in cobalamin (B12) metabolism	12 targets	R-HSA-3296469
Reactome	Defects in vitamin and cofactor metabolism	20 targets	R-HSA-3296482
Reactome	Disease	1105 targets	R-HSA-1643685

Name	Explore in Pharos	Explore in Source
Cobalamin (Cbl, vitamin B12) transport and metabolism	19 targets	R-HSA-196741
Defective CD320 causes methylmalonic aciduria	2 targets	R-HSA-3359485
Defects in cobalamin (B12) metabolism	12 targets	R-HSA-3296469
Defects in vitamin and cofactor metabolism	20 targets	R-HSA-3296482
Disease	1105 targets	R-HSA-1643685

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (4)

Components (5)

Processes (5)

Find Similar Targets

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Direct Assay (IDA)	UniProtKB
cobalamin binding	Inferred from Direct Assay (IDA)	MGI
cobalamin-transporting ATPase activity	Traceable Author Statement (TAS)	Reactome
growth factor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (23)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 23

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	13	8	20	4	99.5
triglyceride measurement	EFO_0004530	9	3	12		98
apolipoprotein A 1 measurement	EFO_0004614	2	3	4		97.1
red blood cell distribution width	EFO_0005192	2	3	4		93.3
very long-chain saturated fatty acid measurement	EFO_0006796	3	2	0	10	91.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 23

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	20	4	99.5
triglyceride measurement	EFO_0004530	12		98
apolipoprotein A 1 measurement	EFO_0004614	4		97.1
red blood cell distribution width	EFO_0005192	4		93.3
very long-chain saturated fatty acid measurement	EFO_0006796	0	10	91.9

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Calcium
Cell membrane
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycoprotein
Growth factor

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
blood metabolite measurement
BMI-adjusted waist-hip ratio
coronary artery disease
diastolic blood pressure
high density lipoprotein cholesterol measurement
lipoprotein measurement
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean reticulocyte volume

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
reproductive system phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (6)

1 – 5 of 6

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	CD320 molecule	VGNC:2367	456436
Macaque	CD320 molecule		711130
Mouse	CD320 antigen	MGI:1860083	54219
Rat	CD320 molecule	RGD:1305860	362851
Dog	CD320 molecule	VGNC:38949	100855567

Species	Name	OMA	EggNOG	Inparanoid
Chimp	CD320 molecule
Macaque	CD320 molecule
Mouse	CD320 antigen
Rat	CD320 molecule
Dog	CD320 molecule

Publication Statistics

PubMed Score 55.82

PubMed score by year

Reset Zoom

PubTator Score 26.37

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (27)

GeneRif Annotations (18)

Items per page:

10

0 of 0

PMID	Year	Title