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Tbio
CD300LF
CMRF35-like molecule 1

Protein Summary
Description
Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301573
  • ENSP00000301573
  • ENSG00000186074
  • ENST00000326165
  • ENSP00000327075
  • ENST00000343125
  • ENSP00000343751
  • ENST00000361254
  • ENSP00000355294
  • ENST00000462044
  • ENSP00000464223
  • ENST00000464910
  • ENSP00000464257
  • ENST00000469092
  • ENSP00000463743
  • ENST00000581500
  • ENSP00000464610

Symbol
  • CD300F
  • CLM1
  • IGSF13
  • IREM1
  • NKIR
  • CLM1
  • NKIR
  • CLM-1
  • IREM1
  • LMIR3
  • CD300f
  • IREM-1
  • IgSF13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.74
protein domain
0.58
cell type or tissue
0.57
cell line
0.56
tissue
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.39   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.39   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0