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Tbio
CD300LF
CMRF35-like molecule 1

Protein Summary
Description
Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301573
  • ENSP00000301573
  • ENSG00000186074
  • ENST00000326165
  • ENSP00000327075
  • ENST00000343125
  • ENSP00000343751
  • ENST00000361254
  • ENSP00000355294
  • ENST00000462044
  • ENSP00000464223
  • ENST00000464910
  • ENSP00000464257
  • ENST00000469092
  • ENSP00000463743
  • ENST00000581500
  • ENSP00000464610

Symbol
  • CD300F
  • CLM1
  • IGSF13
  • IREM1
  • NKIR
  • CLM1
  • NKIR
  • CLM-1
  • IREM1
  • LMIR3
  • CD300f
  • IREM-1
  • IgSF13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.74
protein domain
0.58
cell type or tissue
0.57
cell line
0.56
tissue
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.58   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 278   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.58   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 278   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
Score:  0.874
Data Source:  STRINGDB
INPP5D
Tbio
Family:  Enzyme
Novelty:  0.00630254
Score:  0.764
Data Source:  STRINGDB
PTPN6
Tchem
Family:  Enzyme
Novelty:  0.00535749
Score:  0.684
Data Source:  STRINGDB
NCAM1
Tbio
Novelty:  0.00020994
Score:  0.683
Data Source:  STRINGDB
FCER1G
Tbio
Novelty:  0.00783146
Score:  0.662
Data Source:  STRINGDB
CD200R1
Tbio
Novelty:  0.00868438
Score:  0.646
Data Source:  STRINGDB
CD300C
Tbio
Novelty:  0.00341957
Score:  0.617
Data Source:  STRINGDB
TLR4
Tchem
Novelty:  0.00010863
Score:  0.613
Data Source:  STRINGDB
HCST
Tbio
Novelty:  0.01604587
Score:  0.606
Data Source:  STRINGDB
TREML1
Tbio
Novelty:  0.03513416
Score:  0.597
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
3
3
96.4
C-reactive protein measurement
4
4
5
95.2
lymphocyte count
3
4
4
92.8
myeloid white cell count
2
2
2
91.2
leukocyte count
2
5
5
89.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
96.4
C-reactive protein measurement
5
95.2
lymphocyte count
4
92.8
myeloid white cell count
2
91.2
leukocyte count
5
89.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD300 molecule like family member f
VGNC:9177
468323
Macaque
CD300 molecule like family member f
703830
Mouse
MGI:2442359
246746
Rat
RGD:1309733
287818
Dog
CD300 molecule like family member f
483297
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD300 molecule like family member f
Macaque
CD300 molecule like family member f
Mouse
Rat
Dog
CD300 molecule like family member f
Publication Statistics
PubMed Score 89.58
PubMed score by year
PubTator Score 21.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title